Ozonolysis is a chemical reaction in which ozone (O3) is used as an oxidizing agent to convert alkene and alkyne functional groups into organic compounds containing carbonyl groups. It is a useful method for the selective oxidation of organic compounds and is considered to be a green oxidation route because it uses ozone, a molecule composed of oxygen atoms, which is more environmentally friendly than many other commonly used oxidizing agents. In addition, the by-products of the reaction, which are typically alcohols, are much less toxic than those produced by other oxidation methods.

    In April 2010 Vapourtec announced early trials being carried out as a collaboration between the Gavriilidis and Motherwell labs at University College London.

    Vapourtec Ozonolysis PDF

    The Vapourtec R Series system with a cooled reactor was used as shown below.


    Examples of published literature for Ozonolysis

    Flow assisted synthesis: a key fragment of SR 142948A

    Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale

    • University of Durham, Chemistry, Durham, UK
    View abstract

    The development of a short route to the API ropinirole hydrochloride

    Zeshan Yousufa, Andrew K. Richardsb, Andrew N. Dwyerc, Bruno Linclaua, David C. Harrowven* a

    • a Chemistry, University of Southampton, Highfield, Southampton, UK
    • b GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK
    • c Formally at GlaxoSmithKline Innovation and Sustainable Manufacturing COE, Worthing, UK
    View abstract

    Ozonolysis of some complex organic substrates in flow

    M. D. Roydhouse1, W. B. Motherwell1, A. Constantinou2, A. Gavriilidis2, R. Wheeler3, K. Down3, I. Campbell3

    • 1Dept of Chemistry, University College London, UK
    • 2Dept of Chemical Engineering, University College London, UK
    • 3GSK, Stevenage, UK
    View abstract

    Ozonolysis in Flow Using Capillary Reactors

    M. D. Roydhouse1, A. Ghaini2, A. Constantinou, A. Cantu-Perez2, W. B. Motherwell1, A. Gavriilidis2

    • 1 Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ
    • 2 Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE
    View abstract

    Application Notes regarding Ozonolysis

    No related applications found.

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