There has been much interest in recent years in Ozonolysis as a potentially green oxidation route, and especially in flow ozonolysis.
In April 2010 Vapourtec announced early trials being carried out as a collaboration between the Gavriilidis and Motherwell labs at University College London.
Vapourtec Ozonolysis PDFThe Vapourtec R Series system with a cooled reactor was used as shown below.
Flow assisted synthesis: a key fragment of SR 142948A
Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale
View abstract
- University of Durham, Chemistry, Durham, UK
The development of a short route to the API ropinirole hydrochloride
Zeshan Yousufa, Andrew K. Richardsb, Andrew N. Dwyerc, Bruno Linclaua, David C. Harrowven* a
View abstract
- a Chemistry, University of Southampton, Highfield, Southampton, UK
- b GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK
- c Formally at GlaxoSmithKline Innovation and Sustainable Manufacturing COE, Worthing, UK
Ozonolysis of some complex organic substrates in flow
M. D. Roydhouse1, W. B. Motherwell1, A. Constantinou2, A. Gavriilidis2, R. Wheeler3, K. Down3, I. Campbell3
View abstract
- 1Dept of Chemistry, University College London, UK
- 2Dept of Chemical Engineering, University College London, UK
- 3GSK, Stevenage, UK
Ozonolysis in Flow Using Capillary Reactors
M. D. Roydhouse1, A. Ghaini2, A. Constantinou, A. Cantu-Perez2, W. B. Motherwell1, A. Gavriilidis2
View abstract
- 1 Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ
- 2 Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE
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The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
The Vapourtec E-Series is the perfect introductory system for flow chemistry
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.
