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Ozonolysis

There has been much interest in recent years in Ozonolysis as a potentially green oxidation route, and especially in flow ozonolysis.

In April 2010 Vapourtec announced early trials being carried out as a collaboration between the Gavriilidis and Motherwell labs at University College London.

Vapourtec Ozonolysis PDF

The Vapourtec R Series system with a cooled reactor was used as shown below.

ozonolysis

Examples of published literature for Ozonolysis

Flow assisted synthesis: a key fragment of SR 142948A

Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale

University of Durham, Chemistry, Durham, UK

View abstract

The development of a short route to the API ropinirole hydrochloride

Zeshan Yousuf^a, Andrew K. Richards^b, Andrew N. Dwyer^c, Bruno Linclau^a, David C. Harrowven^{* a}

^a Chemistry, University of Southampton, Highfield, Southampton, UK

^b GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, UK

^c Formally at GlaxoSmithKline Innovation and Sustainable Manufacturing COE, Worthing, UK

View abstract

Ozonolysis of some complex organic substrates in flow

M. D. Roydhouse¹, W. B. Motherwell¹, A. Constantinou², A. Gavriilidis², R. Wheeler³, K. Down³, I. Campbell³

¹Dept of Chemistry, University College London, UK

²Dept of Chemical Engineering, University College London, UK

³GSK, Stevenage, UK

View abstract

Ozonolysis in Flow Using Capillary Reactors

M. D. Roydhouse¹, A. Ghaini², A. Constantinou, A. Cantu-Perez², W. B. Motherwell¹, A. Gavriilidis²

¹ Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ

² Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE

View abstract