Ozonolysis of some complex organic substrates in flow
- M. D. Roydhouse1
- W. B. Motherwell1
- A. Constantinou2
- A. Gavriilidis2
- R. Wheeler3
- K. Down3
- I. Campbell3
- 1Dept of Chemistry, University College London, UK
- 2Dept of Chemical Engineering, University College London, UK
- 3GSK, Stevenage, UK
Read the publication that featured this abstractThe ozonolysis of several organic substrates to give carbonyl compounds, carboxylic acids and nicotinic acids in flow using a standard lab-scale flow system equipped with a cooled flow cell was examined. Alkyl and aryl alkenes showed good conversion (49–99%) to the corresponding aldehydes and ketones utilising an “in flow” quench of triphenylphosphine. The ozonolysis of either 2 or 3-substituted furans obtained furnished a variety of carboxylic acids including the pharmaceutically important oxetane-3-carboxylic acids in two steps from furan and oxetan-3-one. Substituted benzoic acids were generated with high yields in two steps from aryl iodides. The non-selective ozonolysis of quinolines is known to give 2,3-dicarbonyl substituted pyridines, herein we report the selective ozonolysis of 8-hydroquinoline to give 3-[(1E)-3-oxoprop-1-en-1-yl]pyridine-2-carboxylic acid using flow techniques.
Get in touch
For more information on flow chemistry systems and services please use the contact methods below.
Call us on +44 (0)1284 728659 or Email us
Resource Centre
R-Series
![R-Series-home-page apourtec-R-Series-flow-chemistry-system](https://www.vapourtec.com/wp-content/uploads/2014/08/R-Series-home-page-1-300x393.jpg)
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
- Automatable
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
E-Series
![Vapourtec_E-series-medcem Vapourtec E-Series medchem flow chemistry system](https://www.vapourtec.com/wp-content/uploads/2021/03/Vapourtec_E-series-medcem-300x377.jpg)
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
- Affordable
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.