Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

    Xin Li1, Anbang Chen1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1, Kai Guo1

    • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
    • 2 School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
    • 3 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

    Continuous-flow synthesis of coumarin was realized in a tandem microflow system containing two microreactors in this study. Generally, better reaction yield (91%) and less side reaction were obtained in the flow system compared with conventional method. Interestingly, different reaction pathways were observed between continuous-flow system and batch methods.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us

    Request a quote