Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

Xin Li¹, Anbang Chen¹, Yangzhi Zhou¹, Lingling Huang², Zheng Fang², Haifeng Gan¹, Kai Guo¹

• ¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
• ² School of Pharmaceutical Sciences, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
• ³ State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

Continuous-flow synthesis of coumarin was realized in a tandem microflow system containing two microreactors in this study. Generally, better reaction yield (91%) and less side reaction were obtained in the flow system compared with conventional method. Interestingly, different reaction pathways were observed between continuous-flow system and batch methods.

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