Examples of published literature for Biological

Flow nanoprecipitation of size-controlled D-leucine nanoparticles for spray-drying formulations

Bruno Cerra, Gabriele Mosca, Maurizio Ricci, Aurélie Schoubben and Antimo Gioiello

  • Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, I-06122 Perugia, Italy
View abstract

Transaminase‐catalyzed continuous synthesis of biogenic aldehydes

Martina L. Contente a, Francesca Paradisi *a,b

  • a School of Chemistry, University of Nottingham, University Park, Nottingham, NG7, 2RD, United Kingdom
  • b Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern
View abstract

Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids

Yuichi Nakahara *†⊥, Bert Metten , Osamu Tonomura §⊥, Aiichiro Nagaki ∥⊥, Shinji Hasebe §⊥, Jun-ichi Yoshida ⊥#, Francesco Molinari 1

  • New Frontiers Research Group, Frontier Research Laboratories, Institute For Innovation, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-8681, Japan
  • Ajinomoto Bio Pharma Services, Cooppallaan 91, B-9230 Wetteren, Belgium
  • § Department of Chemical Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
  • Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
  • Micro Chemical Production Study Consortium in Kyoto University, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
  • # National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie 510-0294, Japan
View abstract

Self-Sufficient Flow-Biocatalysis by Coimmobilization of Pyridoxal 5′-Phosphate and ω-Transaminases onto Porous Carriers

Ana I. Benítez-Mateos , Martina L. Contente §, Susana Velasco-Lozano , Francesca Paradisi , Fernando López-Gallego *⊥‡

  • Heterogeneous Biocatalysis Laboratory, CICbiomaGUNE, Paseo Miramón 182, Edificio empresarial C”, 20014 San Sebastián, Spain
  • § School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K
  • Heterogeneous biocatalysis laboratory, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH−CSIC), University of Zaragoza, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain
  • ARAID, Aragon I+D foundation, Zaragoza, Spain
View abstract

Self-sustaining closed-loop multienzyme-mediated conversion of amines into alcohols in continuous reactions

Martina L. Contente, Francesca Paradisi

  • School of Chemistry, University of Nottingham, Nottingham, United Kingdom
View abstract

Dichlorophenylacrylonitriles as AhR Ligands displaying selective breast cancer cytotoxicity in vitro

Jennifer R Baker1, Jayne Gilbert2, Stefan Paula3, Xiao Zhu3, Jennette A Sakoff2, Adam McCluskey1

  • 1 The University of Newcastle, Chemistry, Newcastle, Australia
  • 2 Calvary Mater Hospital, Medical Oncology, Newcastle, Australia
  • 3 Purdue University, Chemistry, West Lafayette, United States
View abstract

A combination of flow and batch mode processes for the efficient preparation of mGlu2/3 receptor negative allosteric modulators (NAMs)

Raveendra Panickar Dhanya, Ananda Herath, Douglas J. Sheffler, Nicholas D.P. Cosford

  • Cancer Metabolism and Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA
View abstract

Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification

Serena Mostardaa, Daniela Passerib, Andrea Carottia,1, Bruno Cerraa, Carolina Collivab, Tiziana Benicchib, Antonio Macchiaruloa, Roberto Pellicciarib, Antimo Gioielloa

  • a Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy
  • b TES Pharma, Corso Vannucci, 47, 06121 Perugia, Italy
View abstract

Targeting a mirabegron precursor by BH3-mediated continuous flow reduction process

Sonia De Angelisa, Claudia Carluccia, Modesto de Candiaa, Gabriele Rebuzzinib, Paolo Celestinib, Massimiliano Riscazzib, Renzo Luisia, Leonardo Degennaroa

  • a FLAME-Lab − Flow Chemistry and Microreactor Technology Laboratory, Department of Pharmacy — Drug Sciences, University of Bari “A. Moro” Via E. Orabona 4, Bari 70125, Italy
  • b COSMA S.p.A, Via Colleoni 15/17, Ciserano, BG 24040, Italy
View abstract

Highly efficient oxidation of amines to aldehydes with flow-based biocatalysis

Dr. Martina L. Contente1,2, Federica Dall'Oglio3, Dr. Lucia Tamborini3, Prof. Francesco Molinari4, Prof. Francesca Paradisi1,2

  • 1 School of Chemistry, University of Nottingham, Nottingham, UK
  • 2 UCD School of Chemistry, University College Dublin, Dublin, Ireland
  • 3 Department of Pharmaceutical Sciences, DISFARM, University of Milan, Milan, Italy
  • 4 Department of Food, Environmental and Nutritional Science, DeFENS, University of Milan, Milan, Italy
View abstract

Methanolysis of epoxidized soybean oil in continuous flow conditions

Vincenzo Pantonea, Amelita Grazia Laurensab, Cosimo Annesec, Francesco Fracassib, Caterina Fuscob, Angelo Naccib,c, Antonella Russoa, Lucia D’Accoltib,c

  • a Greenswitch s.r.l., Ferrandina MT, Italy
  • b Dipartimento di Chimica, Università di Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy
  • c ICCOM-CNR, SS Bari, Via E. Orabona 4, 70126 Bari, Italy
View abstract

Chemoenzymatic synthesis in flow reactors: a rapid and convenient preparation of captopril

Dr. Valerio De Vitis1, Dr. Federica Dall'Oglio1, Dr. Andrea Pinto2, Prof. Carlo De Micheli2, Prof. Francesco Molinari1, Prof. Paola Conti2, Dr. Diego Romano1, Dr. Lucia Tamborini2

  • 1 Department of Food Environmental and Nutritional Science, University of Milan, Milan, Italy
  • 2 Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
View abstract

Co-production of HMF and gluconic acid from sucrose by chemo-enzymatic method

Hongli Wu, Ting Huang, Fei Cao, Qiaogen Zou, Ping Wei, Pingkai Ouyang

  • College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816 PR China
View abstract

Direct valorisation of waste cocoa butter triglycerides via catalytic epoxidation, ring-opening and polymerisation

Dorota D Plazaa, Vinzent Strobelb, Parminder Kaur KS Heerb, Andrew B Sellarsd, Seng-Soi Hoongd, Andrew J Clarkd, Alexei A Lapkinb

  • a School of Engineering, University of Warwick, Coventry, UK
  • b Department of Chemical Engineering and Biotechnology, University of Cambridge, UK
  • c Aachener Verfahrenstechnik – Process Systems Engineering, RWTH Aachen University, Aachen, Germany
  • d Department of Chemistry, University of Warwick, Coventry, UK
View abstract

Utilizing on‐and off‐line monitoring tools to follow a kinetic resolution step during flow synthesis

Kathleen A. Farley, Usa Reilly, Dennis P. Anderson, Brian P. Boscoe, Mark W. Bundesmann, David A. Foley, Manjinder S. Lall, Chao Li, Matthew R. Reese, Jiangli Yan

  • Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, CT, United States
View abstract

Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Ananda Herath, Nicholas D. P. Cosford

  • Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
View abstract

Active Site-Mapping of Xylan-Deconstructing Enzymes with Arabinoxylan Oligosaccharides Produced by Automated Glycan Assembly

Deborah Senf, Colin Ruprecht, Goswinus de Kruijff, Sebastian Simonetti, Frank Schuhmacher, Peter Seeberger, Fabian Pfrengle

  • Max-Planck-Institute of Colloids and Interfaces, Biomolecular Systems, Potsdam, Germany
View abstract

Mixed-Linkage Glucan Oligosaccharides Produced by Automated Glycan Assembly Serve as Tools to Determine the Substrate Specificity of Lichenase

Pietro Dallabernardina, Frank Schuhmacher, Peter H Seeberger, Fabian Pfrengle

  • Max-Planck-Institute of Colloids and Interfaces, Biomolecular Systems, Potsdam, Germany
View abstract

γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket

Lucia Tamborinia, Veronica Nicosiaa, Paola Contia, Federica Dall'Oglioa, Carlo De Michelia, Birgitte Nielsenb, Anders A. Jensenb, Darryl S. Pickeringb, Andrea Pintoa

  • a Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
  • b Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen OE, Denmark
View abstract

Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata

Matteo Planchestainera, Martina Letizia Contenteab, Jennifer Cassidya, Francesco Molinarib, Lucia Tamborini*c, Francesca Paradisi*ad

  • * Corresponding authors
  • a UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland
  • b Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
  • c Department of Pharmaceutical Sciences (DISFARM), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
  • d School of Chemistry, University of Nottingham, University Park, Nottingham, UK
View abstract

The generation of a library of bromodomain-containing protein modulators expedited by continuous flow synthesis

Paolo Filipponi and Ian R. Baxendale*

  • * Department of Chemistry, University of Durham South Road, Durham, DH1 3LE, United Kingdom
View abstract

Continuous flow photochemistry as an enabling synthetic technology: synthesis of substituted-6(5H)-phenanthridinones for use as poly(ADP-ribose) polymerase inhibitors

Y. Fang a, G. K. Tranmer *a,b

  • * Corresponding authors a College of Pharmacy, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • b Department of Chemistry, Faculty of Science, University of Manitoba, Winnipeg, Canada
View abstract

Automated glycan assembly of xyloglucan oligosaccharides

Pietro Dallabernardinaa b, Frank Schuhmachera b, Peter H. Seebergera b, Fabian Pfrengle* a b

  • a Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
  • b Freie Universität Berlin, Institute of Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany
View abstract

An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor

Cecilia Russella, Andrew J. S. Lina, Peter Hainsb, Michela I. Simonea, Phillip J. Robinsonb, Adam McCluskey* a

  • A Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan, Australia
  • B Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Australia
View abstract

A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component

Ian R. Baxendale*

  • Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
View abstract

Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng, Karl R. Gibson, Willem P. van Hoorn, James Mills, Trevor Morgan, David M. Parry, Manoj K. Ramjee, Christopher Nicholas Selway, Gary J. Tarver, Gavin Whitlock, Adrian G. Wright

  • Cyclofluidic Ltd.
View abstract

Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

Yan Wua,1, Wei-Qi Chenb,1, Yu-Qing Zhaoc, Hu-Ri Piaoa

  • aKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, China
  • bDepartment of Chemistry, Fudan University, Shanghai, China
  • cSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
View abstract

An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides

Paolo Zambellia, Lucia Tamborinib, Samuele Cazzamallib, Andrea Pintob, Stefania Ariolia, Silvia Balzarettia, Francisco J. Plouc, Lucia Fernandez-Arrojoc, Francesco Molinaria, Paola Contib, Diego Romanoa

  • a Department of Food Environmental and Nutritional Science (DeFENS), University of Milan, Via Mangiagalli, 20133 Milan, Italy
  • b Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
  • c Instituto de Catálisis y Petroleoquímica, CSIC, 28049 Madrid, Spain
View abstract

Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization

Serena Mostardaa, Paolo Filipponia, Roccaldo Sardellaa, Francesco Venturonia, Benedetto Natalinia, Roberto Pellicciariab, Antimo Gioiello*a

  • aLaboratory of Medicinal and Advanced Synthetic Chemistry (Lab MASC), Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy
  • bTES Pharma S.r.l., Corciano, Italy
View abstract

Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure–Activity Relationship Data of ?-Secretase (BACE1) Inhibitors

Dr. Michael Werner1,*, Christoph Kuratli1, Dr. Rainer E. Martin1,*, Dr. Remo Hochstrasser1, David Wechsler1, Dr. Thilo Enderle1, Dr. Alexander I. Alanine1, Prof. Dr. Horst Vogel2

  • 1 Medicinal Chemistry, Small Molecule Research, Pharma Research & Early Development (pRED), F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (Switzerland)
  • 2 Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Station 6, 1015 Lausanne (Switzerland)
View abstract

Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent

Lucia Tamborinia, Diego Romanob, Andrea Pintoa, Martina Contentea, Maria C. Iannuzzia, Paola Contia, Francesco Molinarib

  • a Dipartimento di Scienze Farmaceutiche, Universitá degli Studi di Milano, Italy
  • b Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente (DEFENS), Universitá degli Studi di Milano, Italy
View abstract

Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery

Werngard Czechtizky, Jurgen Dedio, Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng Trevor Morgen, David M Parry, Manoj K. Ramjee, Christopher N. Selway, Thorsten Schmidt, Gary J. Tarver, Adrian G. Wright

  • Sanofi-Aventis, Frankfurt, Germany. Cyclofluidic Ltd., U.K.
View abstract

Synthesis of an H3 Antagonist via Sequential One-Pot Additions of a Magnesium Ate Complex and an Amine to a 1,4-Ketoester followed by Carbonyl-Directed Fluoride Addition

Joel M. Hawkins, Pascal Dubé, Mark T. Maloney, Lulin Wei. Marcus Ewing, Stephen M. Chesnut, Joshua R. Denette, Brett M. Lillie, Rajappa Vaidyanathan

  • Pharmaceutical Sciences, Pfizer Inc., Groton, USA
View abstract

An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor

Lucia Tamborini1, Diego Romano2, Andrea Pinto1, Arianna Bertolani1,2, Francesco Molinari2, Paola Conti1

  • 1Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’, Universitá degli Studi di Milano, Italy
  • 2Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universitá degli Studi di Milano, Italy
View abstract

Lead Diversification 2: Application to P38, gMTP and lead compounds

M. Abid Masood1, Marc Bazin2, Mark E. Bunnage1, Andrew Calabrese3, Mark Cox1, Sally-Ann Fancy1, Elizabeth Farrant1, David W. Pearce1, Manuel Perez1, Laure Hitzel1, Torren Peakman1

  • 1Worldwide Medicinal Chemistry, Pfizer, UK
  • 2Hepatochem, Cambridge, MA, USA
  • 3Celgene San Diego, USA
View abstract

One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation

Adam Sniady, Matthew W. Bedore, Timothy F. Jamison

  • Novartis Institutes for Biomedical Research Inc., Cambridge, USA MIT, Cambridge, USA
View abstract

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