Examples of published literature for Biological

Chemoenzymatic synthesis in flow reactors: a rapid and convenient preparation of captopril

Dr. Valerio De Vitis1, Dr. Federica Dall'Oglio1, Dr. Andrea Pinto2, Prof. Carlo De Micheli2, Prof. Francesco Molinari1, Prof. Paola Conti2, Dr. Diego Romano1, Dr. Lucia Tamborini2

  • 1 Department of Food Environmental and Nutritional Science, University of Milan, Milan, Italy
  • 2 Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
View abstract

Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Ananda Herath, Nicholas D. P. Cosford

  • Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
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Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata

Matteo Planchestainera, Martina Letizia Contenteab, Jennifer Cassidya, Francesco Molinarib, Lucia Tamborini*c, Francesca Paradisi*ad

  • * Corresponding authors
  • a UCD School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland
  • b Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
  • c Department of Pharmaceutical Sciences (DISFARM), Università degli studi di Milano, Via Mangiagalli 25, Milan, Italy
  • d School of Chemistry, University of Nottingham, University Park, Nottingham, UK
View abstract

Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng, Karl R. Gibson, Willem P. van Hoorn, James Mills, Trevor Morgan, David M. Parry, Manoj K. Ramjee, Christopher Nicholas Selway, Gary J. Tarver, Gavin Whitlock, Adrian G. Wright

  • Cyclofluidic Ltd.
View abstract

Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

Yan Wua,1, Wei-Qi Chenb,1, Yu-Qing Zhaoc, Hu-Ri Piaoa

  • aKey Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy, China
  • bDepartment of Chemistry, Fudan University, Shanghai, China
  • cSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
View abstract

Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization

Serena Mostardaa, Paolo Filipponia, Roccaldo Sardellaa, Francesco Venturonia, Benedetto Natalinia, Roberto Pellicciariab, Antimo Gioiello*a

  • aLaboratory of Medicinal and Advanced Synthetic Chemistry (Lab MASC), Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy
  • bTES Pharma S.r.l., Corciano, Italy
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Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure–Activity Relationship Data of ?-Secretase (BACE1) Inhibitors

Dr. Michael Werner1,*, Christoph Kuratli1, Dr. Rainer E. Martin1,*, Dr. Remo Hochstrasser1, David Wechsler1, Dr. Thilo Enderle1, Dr. Alexander I. Alanine1, Prof. Dr. Horst Vogel2

  • 1 Medicinal Chemistry, Small Molecule Research, Pharma Research & Early Development (pRED), F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (Switzerland)
  • 2 Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Station 6, 1015 Lausanne (Switzerland)
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Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent

Lucia Tamborinia, Diego Romanob, Andrea Pintoa, Martina Contentea, Maria C. Iannuzzia, Paola Contia, Francesco Molinarib

  • a Dipartimento di Scienze Farmaceutiche, Universitá degli Studi di Milano, Italy
  • b Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente (DEFENS), Universitá degli Studi di Milano, Italy
View abstract

Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery

Werngard Czechtizky, Jurgen Dedio, Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng Trevor Morgen, David M Parry, Manoj K. Ramjee, Christopher N. Selway, Thorsten Schmidt, Gary J. Tarver, Adrian G. Wright

  • Sanofi-Aventis, Frankfurt, Germany. Cyclofluidic Ltd., U.K.
View abstract

An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor

Lucia Tamborini1, Diego Romano2, Andrea Pinto1, Arianna Bertolani1,2, Francesco Molinari2, Paola Conti1

  • 1Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’, Universitá degli Studi di Milano, Italy
  • 2Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universitá degli Studi di Milano, Italy
View abstract

Lead Diversification 2: Application to P38, gMTP and lead compounds

M. Abid Masood1, Marc Bazin2, Mark E. Bunnage1, Andrew Calabrese3, Mark Cox1, Sally-Ann Fancy1, Elizabeth Farrant1, David W. Pearce1, Manuel Perez1, Laure Hitzel1, Torren Peakman1

  • 1Worldwide Medicinal Chemistry, Pfizer, UK
  • 2Hepatochem, Cambridge, MA, USA
  • 3Celgene San Diego, USA
View abstract

One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation

Adam Sniady, Matthew W. Bedore, Timothy F. Jamison

  • Novartis Institutes for Biomedical Research Inc., Cambridge, USA MIT, Cambridge, USA
View abstract

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