Examples of published literature for Coupling reactions

Continuous preparation for rifampicin

Xin Li 1, Zhuang Liu 1, Zheng Fang 1, Hao Qi 1, Siyu Huang 1, Shanshan Miao 1, Kai Guo 1,2

  • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
  • 2 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China
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A Flow-based Synthesis of Telmisartan

Alex Martin, Ali Siamaki, Katherine Belecki, B. Gupton

  • Department of Chemistry and Department of Chemical and Life Science Engineering Virginia Commonwealth University 601 W. Main St. Richmond Virginia 23284 United States
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Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

Nerea Alonso2,3, L. Zane Miller1, Juan de M. Muñoz2, Jesus Alcázar2,*, D. Tyler McQuade1,*

  • 1Department of Chemistry and Biochemistry, Florida State University, USA
  • 2Janssen Research and Development, Janssen-Cilag, Toledo, Spain
  • 3Facultad de Química, Universidad de Castilla-La Mancha, Spain
View abstract

Robust and reusable supported palladium catalysts for cross-coupling reactions in flow

William R. Reynoldsab, Pawel Plucinskibc, Christopher G. Frost*ab

  •   * Corresponding authors
  • a Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath, UK
  • b Department of Chemistry, University of Bath, Claverton Down, Bath, UK
  • c Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK
View abstract

Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts

Claudio Battilocchio1, Benjamin N. Bhawal1, Rajeev Chorghade1, Benjamin J. Deadman1, Joel M. Hawkins2, Steven V. Ley1

  • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, UK
  • 2 Pfizer Worldwide Research & Development, Groton, USA
View abstract

Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow

Timothy Noël, Andrew J. Musacchio

  • Department of Chemistry, MIT, USA
View abstract

Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

Yun Zhang1, Timothy F. Jamison2, Sejal Patel1, Nello Mainolfi1, 1Novartis Institutes for Biomedical Research Inc., Cambridge, USA, 2MIT, Cambridge, USA

View abstract

Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids

Luke R. Odell1, Jonas Lindh1, Tomas Gustafsson2, Mats Larhed1*

  • 1Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden
  • 2AstraZeneca R&D Mölndal, Sweden
View abstract

Application Notes regarding Coupling reactions

Application Note 49 – Suzuki Coupling with SiliaCat DPP-Pd Heterogeneous Catalyst


In this application, a Vapourtec R-Series has been used to achieve rapid reaction times and high conversion of a Suzuki coupling, using a commercially available supported palladium catalyst. With a reaction time of just 1 min 15 seconds, it was possible to achieve yields of over 80%, at greater than 95% purity following a simple chromatographic separation. This application demonstrates how the Vapourtec R-Series can be used as a tool for the synthetic flow chemist, or for a development chemist beginning the scale up process.

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