Examples of published literature for Coupling reactions

Continuous preparation for rifampicin

Xin Li 1, Zhuang Liu 1, Zheng Fang 1, Hao Qi 1, Siyu Huang 1, Shanshan Miao 1, Kai Guo 1,2

  • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
  • 2 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China
View abstract

An efficient benzoxaborole one‐pot synthesis by SiliaCat DPP‐Pd heterogeneous catalysis using diboronic acid

Kana kunihiro1, Laurence Dumais2, Guillaume Lafitte2, Emeric Varvier2, Loïc Tomas2, Craig Harris2

  • 1 Ecole Nationale Supérieure des Ingenieurs en Arts Chimiques et Technologiques, France
  • 2 Nestlé Skin Health, Galderma R&D, France
View abstract

Functionalization of Heteroarenes Under Continuous Flow

Joachim Demaerel, Vidmantas Bieliũnas, Wim M. De Borggraeve

  • Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Leuven, Belgium
View abstract

Photoredox Iridium–Nickel Dual-Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self-Optimizing Segmented Flow Reactor

Hsiao-Wu Hsieh, Connor W. Coley, Lorenz M. Baumgartner, Klavs F. Jensen*‡, Richard I. Robinson*†

  • Global Discovery Chemistry − Chemical Technology Group, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
  • Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
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Flow assisted synthesis: a key fragment of SR 142948A

Matthew Oliver Kitching, Olivia E Dixon, Marcus Baumann, Ian Richard Baxendale

  • University of Durham, Chemistry, Durham, UK
View abstract

Phase separation macrocyclization in a complex pharmaceutical setting: application toward the synthesis of vaniprevir

Eric Godin, Anne-Catherine Bédard, Michael Raymond, Shawn K. Collins*

  • Département de Chimie, Centre for Green Chemistry and Catalysis, Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7 Canada
View abstract

A Flow-based Synthesis of Telmisartan

Alex Martin, Ali Siamaki, Katherine Belecki, B. Gupton

  • Department of Chemistry and Department of Chemical and Life Science Engineering Virginia Commonwealth University 601 W. Main St. Richmond Virginia 23284 United States
View abstract

Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

Nerea Alonso2,3, L. Zane Miller1, Juan de M. Muñoz2, Jesus Alcázar2,*, D. Tyler McQuade1,*

  • 1Department of Chemistry and Biochemistry, Florida State University, USA
  • 2Janssen Research and Development, Janssen-Cilag, Toledo, Spain
  • 3Facultad de Química, Universidad de Castilla-La Mancha, Spain
View abstract

Robust and reusable supported palladium catalysts for cross-coupling reactions in flow

William R. Reynoldsab, Pawel Plucinskibc, Christopher G. Frost*ab

  •   * Corresponding authors
  • a Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath, UK
  • b Department of Chemistry, University of Bath, Claverton Down, Bath, UK
  • c Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK
View abstract

Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts

Claudio Battilocchio1, Benjamin N. Bhawal1, Rajeev Chorghade1, Benjamin J. Deadman1, Joel M. Hawkins2, Steven V. Ley1

  • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, UK
  • 2 Pfizer Worldwide Research & Development, Groton, USA
View abstract

Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow

Timothy Noël, Andrew J. Musacchio

  • Department of Chemistry, MIT, USA
View abstract

Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

Yun Zhang1, Timothy F. Jamison2, Sejal Patel1, Nello Mainolfi1, 1Novartis Institutes for Biomedical Research Inc., Cambridge, USA, 2MIT, Cambridge, USA

View abstract

Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids

Luke R. Odell1, Jonas Lindh1, Tomas Gustafsson2, Mats Larhed1*

  • 1Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden
  • 2AstraZeneca R&D Mölndal, Sweden
View abstract

Application Notes regarding Coupling reactions

Application Note 49 – Suzuki Coupling with SiliaCat DPP-Pd Heterogeneous Catalyst


In this application, a Vapourtec R-Series has been used to achieve rapid reaction times and high conversion of a Suzuki coupling, using a commercially available supported palladium catalyst. With a reaction time of just 1 min 15 seconds, it was possible to achieve yields of over 80%, at greater than 95% purity following a simple chromatographic separation. This application demonstrates how the Vapourtec R-Series can be used as a tool for the synthetic flow chemist, or for a development chemist beginning the scale up process.

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