Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2) C(sp3) cross-coupling

• Irini Abdiaj, Jesús Alcázar

• Janssen Research and Development, Janssen-Cilag, S.A., C/Jarama 75, 45007 Toledo, Spain

We report herein the transfer of dual photoredox and nickel catalysis for C(sp2)single bondC(sp3) cross coupling form batch to flow. This new procedure clearly improves the scalability of the previous batch reaction by the reactor’s size and operating time reduction, and allows the preparation of interesting compounds for drug discovery in multigram amounts.

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