Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids

Palladium(II)-catalyzed oxidative Heck reactions were investigated under continuous flow conditions. Selective, fast and convenient protocols for the coupling of arylboronic acids with electron-rich and electron-poor olefins were developed by using a commercially available flow reactor.

• Luke R. Odell¹
• Jonas Lindh¹
• Tomas Gustafsson²
• Mats Larhed^1*

• ¹Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden
• ²AstraZeneca R&D Mölndal, Sweden

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