Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids

    Luke R. Odell1, Jonas Lindh1, Tomas Gustafsson2, Mats Larhed1*

    • 1Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden
    • 2AstraZeneca R&D Mölndal, Sweden

    Palladium(II)-catalyzed oxidative Heck reactions were investigated under continuous flow conditions. Selective, fast and convenient protocols for the coupling of arylboronic acids with electron-rich and electron-poor olefins were developed by using a commercially available flow reactor.

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