The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact
- Trine P. Petersen1,2,3
- Anastasios Polyzos1,4
- Matthew O’Brien1
- Trond Ulven2
- Ian R. Baxendale1
- Steven V. Ley1
- 1Whiffen Laboratory, University of Cambridge, UK
- 2Department of Physics and Chemistry, University of Southern Denmark
- 3Discovery Chemistry and DMPK, H. Lundbeck A/S,Denmark
- 4CSIRO, Materials Science and Engineering, AustraliaRead the publication that featured this abstract
The gas is always greener: A continuous flow Glaser–Hay coupling reaction system, mediated by molecular oxygen, is developed based on a tube-in-tube gas/liquid reactor/injector. The system uses a semi-permeable Teflon AF-2400 membrane to effect rapid gas/liquid contact in flow, affording homogeneous solutions of oxygen. Measurements of out-gassing downstream of the back-pressure regulator indicate the onset of saturation is reached after about 16 seconds.
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