The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

• Trine P. Petersen^1,2,3
• Anastasios Polyzos^1,4
• Matthew O’Brien¹
• Trond Ulven²
• Ian R. Baxendale¹
• Steven V. Ley¹

• ¹Whiffen Laboratory, University of Cambridge, UK
• ²Department of Physics and Chemistry, University of Southern Denmark
• ³Discovery Chemistry and DMPK, H. Lundbeck A/S,Denmark
• ⁴CSIRO, Materials Science and Engineering, Australia

The gas is always greener: A continuous flow Glaser–Hay coupling reaction system, mediated by molecular oxygen, is developed based on a tube-in-tube gas/liquid reactor/injector. The system uses a semi-permeable Teflon AF-2400 membrane to effect rapid gas/liquid contact in flow, affording homogeneous solutions of oxygen. Measurements of out-gassing downstream of the back-pressure regulator indicate the onset of saturation is reached after about 16 seconds.

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