Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing
- Yun Zhang1
- Timothy F. Jamison2
- Sejal Patel1
- Nello Mainolfi1
- 1Novartis Institutes for Biomedical Research Inc., Cambridge, USA
- 2MIT, Cambridge, USA
Read the publication that featured this abstractA convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.
Get in touch
For more information on flow chemistry systems and services please use the contact methods below.
Call us on +44 (0)1284 728659 or Email us
R-Series
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
- Automatable
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
E-Series
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
- Affordable
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.
