Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.

• Yun Zhang¹
• Timothy F. Jamison²
• Sejal Patel¹
• Nello Mainolfi¹
• ¹Novartis Institutes for Biomedical Research Inc., Cambridge, USA
• ²MIT, Cambridge, USA

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