Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

    • Yun Zhang1
    • Timothy F. Jamison2
    • Sejal Patel1
    • Nello Mainolfi1
    • 1Novartis Institutes for Biomedical Research Inc., Cambridge, USA
    • 2MIT, Cambridge, USA

    A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us

    Request a quote