Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing
- Yun Zhang1
- Timothy F. Jamison2
- Sejal Patel1
- Nello Mainolfi1
- 1Novartis Institutes for Biomedical Research Inc., Cambridge, USA
- 2MIT, Cambridge, USARead the publication that featured this abstract
A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.
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