Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

    • Yun Zhang1
    • Timothy F. Jamison2
    • Sejal Patel1
    • Nello Mainolfi1
    • 1Novartis Institutes for Biomedical Research Inc., Cambridge, USA
    • 2MIT, Cambridge, USA

    A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.

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