Continuous preparation for rifampicin

• Xin Li ¹
• Zhuang Liu ¹
• Zheng Fang ¹
• Hao Qi ¹
• Siyu Huang ¹
• Shanshan Miao ¹
• Kai Guo ^1,2

• ¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
• ² State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China

To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

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