Continuous preparation for rifampicin

    • Xin Li 1
    • Zhuang Liu 1
    • Zheng Fang 1
    • Hao Qi 1
    • Siyu Huang 1
    • Shanshan Miao 1
    • Kai Guo 1,2
    • 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
    • 2 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, China

    To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us