Continuous preparation for rifampicin
- Xin Li 1
- Zhuang Liu 1
- Zheng Fang 1
- Hao Qi 1
- Siyu Huang 1
- Shanshan Miao 1
- Kai Guo 1,2
- 1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China
- 2 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, ChinaRead the publication that featured this abstract
To reduce the cost and improve the efficiency for rifampicin preparation, a continuous flow synthesis of rifampicin starting from rifamycin S and tert-butylamine was studied in a microreactor. Two reaction steps and one purification step were coupled in a microreactor, and rifampicin was obtained with 67% overall yield. This method used 25% less 1-amino-4-methyl piperazine and got 16% higher overall yield without changing solvent and purification process between steps. This method has a good potential for further industrial application.
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible :
- Precise :
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust :
- Easy to use :
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.