A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow
Yiding Chen†, Oliver May†, David C. Blakemore‡, and Steven V. Ley†*
- † Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
- †‡ Medicine Design, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United StatesRead the publication that featured this abstract
Mild cross-coupling reaction between benzylboronic esters with carbonyl compounds and some imines was achieved under visible-light-induced iridium-catalyzed photoredox conditions. Functional group tolerance was demonstrated by 51 examples, including 13 heterocyclic compounds. Gram-scale reaction was realized through the use of computer-controlled continuous flow photoreactors.
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