Multistep synthesis
Examples of published literature for Multistep synthesis
A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles
Edouard Godineau *†, Claudio Battilocchio †‡, Matthias Lehmann †, Steven V. Ley †, Ricardo Labes ‡, Letitia Birnoschi ‡, Srinivas Subramanian §, C.S Prasanna § , Amol Gorde §, Mahesh Kalbagh §, Vivek Khade §, Anton Scherrer †, Anthony C. O’Sullivan †
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- † Syngenta Crop Protection, Process Research, Schaffhauserstrasse 101, CH-4332, Switzerland
- ‡ Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK
- § Syngenta Research and Technology Centre, Santa Monica Works, Corlim, Goa India, 403110
Multistep Continuous-Flow Processes for the Preparation of Heterocyclic Active Pharmaceutical Ingredients
Romaric Gérardy, Jean-Christophe M. Monbaliu
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- Center for Integrated Technology and Organic Synthesis, Department of Chemistry, University of Liège, Liège, Belgium
Telescoped continuous flow generation of a library of highly substituted 3-thio-1,2,4-triazoles.
Mariana C. F. C. B. Damiãoa, Renan Galavernaa, Alan P. Kozikowskib, James Eubanksc, Julio C. Pastrea
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- a Institute of Chemistry, University of Campinas - UNICAMP, PO Box 6154 - Zip Code 13083-970, Campinas, SP, Brazil
- b StarWise Therapeutics LLC - University Research Park – Zip Code 53719-1235, Madison, Wisconsin, USA
- c Division of Genetics and Development - Krembil Research Institute – Zip Code M5T 2S8, Toronto, Ontario, Canada
A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component
Ian R. Baxendale*
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- Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, UK
A Concise Flow Synthesis of Efavirenz†
Dr. Camille A. Correia1, Dr. Kerry Gilmore1, Prof. Dr. D. Tyler McQuade3, Prof. Dr. Peter H. Seeberger1 2 *
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- 1 Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)
- 2 Institute for Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin (Germany)
- 3 Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306 (USA)
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent
Catherine J. Smith, Christopher D. Smith, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale
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- Innovative Technology Centre, Cambridge, UK
Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide
Richard J. Ingham1, Claudio Battilocchio1, Joel M. Hawkins2, Steven V. Ley1
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- 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK
- 2 Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA
Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis
D. Tyler McQuade1 3, Peter H. Seeberger1 2
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- 1 Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces
- 2 Institute for Chemistry and Biochemistry, Freie Universität Berlin,
- 3 Department of Chemistry and Biochemistry, Florida State University
An expeditious synthesis of imatinib and analogues utilising flow chemistry methods
Mark D Hopkin, Ian Baxendale, Steven.V.Ley
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- Dept of Chemistry, University of Cambridge, UK
A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids
Yuji Nakano1, G. Paul Savage1, Simon Saubern1, Peter J. Scammells2, Anastasios Polyzos1
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- 1 CSIRO Materials Science and Engineering, Victoria, Australia.
- 2 Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia.
A Two-Stage Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes
Mark York123, Adriana Edenharter1
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- 1CSIRO Materials Science and Engineering, Clayton, Vic. 3169, Australia.
- 2Cooperative Research Centre for Polymers, Notting Hill, Vic. 3168, Australia.
- 3Advanced Polymerik Pty Ltd, Notting Hill, Vic. 3168, Australia.
Synthesis of an H3 Antagonist via Sequential One-Pot Additions of a Magnesium Ate Complex and an Amine to a 1,4-Ketoester followed by Carbonyl-Directed Fluoride Addition
Joel M. Hawkins, Pascal Dubé, Mark T. Maloney, Lulin Wei. Marcus Ewing, Stephen M. Chesnut, Joshua R. Denette, Brett M. Lillie, Rajappa Vaidyanathan
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- Pharmaceutical Sciences, Pfizer Inc., Groton, USA
Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands
Claudio Battilocchio1,3, Marcus Baumann1, Ian R. Baxendale1, Mariangela Biava3, Matthew O. Kitching1, Steven V. Ley1, Rainer E. Martin*2, Stephan A. Ohnmacht2, Nicholas D. C. Tappin1
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- 1Department of Chemistry, University of Cambridge, UK
- 2F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland
- 3Department of Pharmaceutical Chemistry and Technology, Sapienza University of Rome, Italy
Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods
Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1, Christoph Kuratli2, Rainer E. Martin2, Josef Schneider2
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- 1Innovative Technology Centre, University of Cambridge, U.K.
- 2F. Hoffmann-La Roche Ltd., Basel, Switzerland
Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies
Elena Riva2, Anna Rencurosi1, Stefania Gagliardi1, Daniele Passarella2, Marisa Martinelli1*
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- 1NiKem Research S.r.l., Milan, Italy
- 2Università degli Studi di Milano,Milan, Italy
Preparation of fluoxetine by multiple flow processing steps
Batoul Ahmed-Omer, Adam J. Sanderson
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- Eli Lilly and Co. Ltd.
- Lilly Research Centre, UK.
Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly
Catherine F. Carter1, Heiko Lange1, Daiki Sakai2, Ian R. Baxendale1, Steven V. Ley1
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- 1Innovative Technology Centre, University of Cambridge, UK, CB2 1EW, UK
- 2Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles
Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange, Ian R. Baxendale
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- Innovative Technology Centre, Cambridge, UK
A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing
Heiko Lange1, Catherine F. Carter1, Mark D. Hopkin1, Adrian Burke2, Jon G. Goode2, Ian R. Baxendale1, Steven V. Ley1
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- 1Innovative Technology Centre, University of Cambridge, UK
- 2Mettler-Toledo AutoChem UK
Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor
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Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor
Laia Malet-Sanz, Julia Madrzak, Steven V.Ley, Ian R.Baxendale
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- Innovative Technology Centre, University of Cambridge
Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor
Marcus Baumann, Ian R. Baxendale, Andreas Kirschning, Steven V. Ley*, Jens Wegner
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- Department of Chemistry, University of Cambridge
Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids
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The application of flow microreactors to the preparation of a family of casein kinase I inhibitors
Francesco Venturoni, Nikzad Nikbin, Steven V. Ley, Ian R. Baxendale
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- Innovative Technology Centre, Department of Chemistry, University of Cambridge
A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester
Lucia Tamborini, Paola Conti, Andrea Pinto, Carlo De Micheli
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- Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’,
- Università degli Studi di Milano, Italy
Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis
Ian R. Baxendale1, Søren C. Schou2, Jörg Sedelmeier1, Steven V. Ley1
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- 1ITC, Department of Chemistry, University of Cambridge
- 2LEO Pharma, Medicinal Chemistry Research, Denmark
Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles
Ian R. Baxendale1, Steven V. Ley1, Andrew C. Mansfield2, Christopher D. Smith1
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- 1ITC, Department of Chemistry, University of Cambridge,
- 2Pfizer Global R&D Research Centre, Sandwich, (UK)
Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation
E. Riva1, S. Gagliardi2, Caterina Mazzoni2, M. Martinelli2, D. Passarella1, D. Vigo2, A. Rencurosi2
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- 1Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Italy
- 2NiKem Research S.r.l., Milan, Italy
Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor
Christopher D. Smith, Ian Baxendale, Geoffrey Tranmer, Marcus Baumann, Stephen Smith, Russell Lewthwaite, Steven V. Ley
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- Department of Chemistry, University of Cambridge, UK
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly
Ian R. Baxendale, Jon Deeley, Charlotte M. Griffiths-Jones, Steven V. Ley, Steen Saaby, Geoffrey K. Tranmer
View abstract
- Innovative Technology Centre, University of Cambridge
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