Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor
- Laetitia J. Martin1
- Andreas L. Marzinzik1
- Steven V. Ley2
- Ian R. Baxendale2
- 1Novartis Institute for BioMedical Research, Basel, Switzerland
- 2Innovative Technology Centre, Department of Chemistry, University of CambridgeRead the publication that featured this abstract
A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases an efficient in-line purification using supported scavengers with time-saving and safety benefits and in particular a reduction in the operator’s exposure to carcinogenic phenylenediamines.
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