Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis
- Ian R. Baxendale1
- Søren C. Schou2
- Jörg Sedelmeier1
- Steven V. Ley1
- 1ITC, Department of Chemistry, University of Cambridge
- 2LEO Pharma, Medicinal Chemistry Research, DenmarkRead the publication that featured this abstract
Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yne[BOND]ones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configuration that allows for easy batch splitting and the generation of a heterocyclic library is described (see scheme).
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