Photodecarboxylations in an advanced meso-scale continuous flow photoreactor

Sam Josland¹, Saira Mumtaz², Michael Oelgemöller^{2 *}

• ¹ University of Southampton, Department of Chemistry, University Road, Southampton, SO17 1BJ, United Kingdom
• ² James Cook University, College of Science, Technology and Engineering, Townsville, QLD 4811, Australia

Selected photodecarboxylations of phthalimides were realized under continuous-flow conditions using an advanced meso-scale photoreactor. The improved efficiency, yields, and productivities of these photochemical reactions highlight the benefits of using flow as opposed to conventional batch operation modes. Flow chemistry furthermore allows for an easy combination of multiple reaction steps in series. This is demonstrated by the successful synthesis of a pharmaceutical target molecule through a tandem photochemical-thermal procedure carried out in uninterrupted flow.

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