Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Added on:
25 Jan, 2012

A series of PyBox ligands were prepared from commercially available chelidonic acid by a multistep flow sequence using mesoreactor technology. A chloro group introduced onto the ligand scaffold was subsequently exploited to give amine derivatives ready for immobilization through microencapsulation technologies.

  • Claudio Battilocchio1,3
  • Marcus Baumann1
  • Ian R. Baxendale1
  • Mariangela Biava3
  • Matthew O. Kitching1
  • Steven V. Ley1
  • Rainer E. Martin*2
  • Stephan A. Ohnmacht2
  • Nicholas D. C. Tappin1
  • 1Department of Chemistry, University of Cambridge, UK
  • 2F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland
  • 3Department of Pharmaceutical Chemistry and Technology, Sapienza University of Rome, Italy
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