Chemical Assembly Systems: Layered Control for Divergent, Continuous, Multistep Syntheses of Active Pharmaceutical Ingredients
Dr. Diego Ghislieri, Dr. Kerry Gilmore, Prof. Dr. Peter H. Seeberger*
- Department of Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Universität Berlin, GermanyRead the publication that featured this abstract
While continuous chemical processes have attracted both academic and industrial interest, virtually all active pharmaceutical ingredients (APIs) are still produced by using multiple distinct batch processes. To date, methods for the divergent multistep continuous production of customizable small molecules are not available. A chemical assembly system was developed, in which flow-reaction modules are linked together in an interchangeable fashion to give access to a wide breadth of chemical space. Control at three different levels—choice of starting material, reagent, or order of reaction modules—enables the synthesis of five APIs that represent three different structural classes (γ-amino acids, γ-lactams, β-amino acids), including the blockbuster drugs Lyrica and Gabapentin, in good overall yields (49–75 %).
We gratefully acknowledge financial support from the Max-Planck Society. We thank Dr. D. Kopetzki for helpful discussions, Dr. M. Rasparini from providing a pure sample of Pregabalin and Thales Nano for providing the H-Cube hydrogenator.
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