Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

Added on:
16 Apr, 2007

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.

  • Christopher D. Smith
  • Ian Baxendale
  • Geoffrey Tranmer
  • Marcus Baumann
  • Stephen Smith
  • Russell Lewthwaite
  • Steven V. Ley
  • Department of Chemistry, University of Cambridge, UK
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