Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

    • Christopher D. Smith
    • Ian Baxendale
    • Geoffrey Tranmer
    • Marcus Baumann
    • Stephen Smith
    • Russell Lewthwaite
    • Steven V. Ley
    • Department of Chemistry, University of Cambridge, UK

    The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us