Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

    • Christopher D. Smith
    • Ian Baxendale
    • Geoffrey Tranmer
    • Marcus Baumann
    • Stephen Smith
    • Russell Lewthwaite
    • Steven V. Ley
    • Department of Chemistry, University of Cambridge, UK

    The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.

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