Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor
- Christopher D. Smith
- Ian Baxendale
- Geoffrey Tranmer
- Marcus Baumann
- Stephen Smith
- Russell Lewthwaite
- Steven V. Ley
- Department of Chemistry, University of Cambridge, UKRead the publication that featured this abstract
The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.
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