Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

• Christopher D. Smith
• Ian Baxendale
• Geoffrey Tranmer
• Marcus Baumann
• Stephen Smith
• Russell Lewthwaite
• Steven V. Ley

• Department of Chemistry, University of Cambridge, UK

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.

Read the publication that featured this abstract