Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Here we describe general flow processes for the synthesis of alkyl and aryl azides, and the development of a new monolithic triphenylphosphine reagent, which provides a convenient format for the use of this versatile reagent in flow. The utility of these new tools was demonstrated by their application to a flow Staudinger aza-Wittig reaction sequence. Finally, a multistep aza-Wittig, reduction and purification flow process was designed, allowing access to amine products in an automated fashion.

• Catherine J. Smith
• Christopher D. Smith
• Nikzad Nikbin
• Steven V. Ley
• Ian R. Baxendale

• Innovative Technology Centre, Cambridge, UK

• Request a Brochure
• Request more Info
• Request a Quote