Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor

• Laia Malet-Sanz
• Julia Madrzak
• Steven V.Ley
• Ian R.Baxendale

• Innovative Technology Centre, University of Cambridge

A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labour intensive way than the corresponding batch method.

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