A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids
- Yuji Nakano1
- G. Paul Savage1
- Simon Saubern1
- Peter J. Scammells2
- Anastasios Polyzos1
- 1 CSIRO Materials Science and Engineering, Victoria, Australia.
- 2 Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia.Read the publication that featured this abstract
Dextromethorphan was N-demethylated using the non-classical Polonovski reaction under continuous flow conditions, in two steps: initial N-oxidation with m-chloroperbenzoic acid followed by iron-catalysed N-demethylation of the resulting N-oxide.
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