A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids

    • Yuji Nakano1
    • G. Paul Savage1
    • Simon Saubern1
    • Peter J. Scammells2
    • Anastasios Polyzos1
    • 1 CSIRO Materials Science and Engineering, Victoria, Australia.
    • 2 Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia.

    Dextromethorphan was N-demethylated using the non-classical Polonovski reaction under continuous flow conditions, in two steps: initial N-oxidation with m-chloroperbenzoic acid followed by iron-catalysed N-demethylation of the resulting N-oxide.

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