Preparation of fluoxetine by multiple flow processing steps

• Batoul Ahmed-Omer
• Adam J. Sanderson

• Eli Lilly and Co. Ltd.
• Lilly Research Centre, UK.

Microflow technology is established as a modern and fashionable tool in synthetic organic chemistry, bringing great improvement and potential, on account of a series of advantages over flask methods. The study presented here focuses on the application of flow chemistry process in performing an efficient multiple step syntheses of (±)-fluoxetine as an alternative to conventional synthetic methods, and one of the few examples of total synthesis accomplished by flow technique.

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