Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

    • Ian R. Baxendale1
    • Steven V. Ley1
    • Andrew C. Mansfield2
    • Christopher D. Smith1
    • 1ITC, Department of Chemistry, University of Cambridge,
    • 2Pfizer Global R&D Research Centre, Sandwich, (UK)

    Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed azide–alkyne cycloaddition sequence without isolation of intermediates (see scheme).

    Read the publication that featured this abstract

    Get in touch

    For more information on flow chemistry systems and services please use the contact methods below.

    Call us on +44 (0)1284 728659 or Email us

    Request a quote