Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles
- Ian R. Baxendale1
- Steven V. Ley1
- Andrew C. Mansfield2
- Christopher D. Smith1
- 1ITC, Department of Chemistry, University of Cambridge,
- 2Pfizer Global R&D Research Centre, Sandwich, (UK)Read the publication that featured this abstract
Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed azide–alkyne cycloaddition sequence without isolation of intermediates (see scheme).
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