Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed azide–alkyne cycloaddition sequence without isolation of intermediates (see scheme).

• Ian R. Baxendale¹
• Steven V. Ley¹
• Andrew C. Mansfield²
• Christopher D. Smith¹

• ¹ITC, Department of Chemistry, University of Cambridge,
• ²Pfizer Global R&D Research Centre, Sandwich, (UK)

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