Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

    • Richard J. Ingham1
    • Claudio Battilocchio1
    • Joel M. Hawkins2
    • Steven V. Ley1
    • 1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK
    • 2 Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA

    Here we describe the use of a new open-source software package and a Raspberry Pi® computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide – a component of Rifater®, used in the treatment of tuberculosis – and its reduced derivative piperazine-2-carboxamide.

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