Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

• Richard J. Ingham¹
• Claudio Battilocchio¹
• Joel M. Hawkins²
• Steven V. Ley¹

• ¹ Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK
• ² Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA

Here we describe the use of a new open-source software package and a Raspberry Pi® computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide – a component of Rifater®, used in the treatment of tuberculosis – and its reduced derivative piperazine-2-carboxamide.

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