A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

    • Catherine J. Smith
    • Nikzad Nikbin
    • Steven V. Ley
    • Heiko Lange
    • Ian R. Baxendale
    • Innovative Technology Centre, Cambridge, UK

    Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a tool for real-time detection of hazardous azide contaminants. This azide synthesis and purification process was then incorporated into a multistep flow sequence to generate a small collection of 5-amino-4-cyano-1,2,3-triazoles directly from aniline starting materials in a fully automated fashion.

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