A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

• Catherine J. Smith
• Nikzad Nikbin
• Steven V. Ley
• Heiko Lange
• Ian R. Baxendale

• Innovative Technology Centre, Cambridge, UK

Having demonstrated in the preceding publication the flow synthesis of aryl azides, we describe here a general protocol for the in-line purification of these versatile intermediates. As part of this investigation, we evaluated the use of ReactIR 45m as a tool for real-time detection of hazardous azide contaminants. This azide synthesis and purification process was then incorporated into a multistep flow sequence to generate a small collection of 5-amino-4-cyano-1,2,3-triazoles directly from aniline starting materials in a fully automated fashion.

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