A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester

• Lucia Tamborini
• Paola Conti
• Andrea Pinto
• Carlo De Micheli

• Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’,
• Università degli Studi di Milano, Italy

The multi-step preparation of N-Boc-3,4-dehydro-l-proline methyl ester using a modular flow reactor is reported. The use of immobilised reagents and scavengers in pre-packed glass tubes allows us to obtain the pure product in 87% overall yield, 97% purity, and >98% enantiomeric excess without any additional purification step. Our flow-based protocol enables the rapid multi-gram synthesis (about 9 g/12 h) of the desired product.

Read the publication that featured this abstract