New application note released: biphasic oxidation reaction scale-up
All News
Handling highly reactive lithium intermediates
Date: 21 November 2016 | Category: News
Professor Wirth and his team at Cardiff have used a Vapourtec E-series to safely generate and handle a highly reactive diazolithium species that reacts highly exothermally. The Vapourtec E-Series allows Professor Wirth to access this highly energetic chemistry, which would be very challenging in batch.
Vapourtec exhibit at London catalysis event
Date: 27 October 2016 | Category: News
Vapourtec will be demonstrating their easy-MedChem flow chemistry system and UV-150 photochemical reactor at the Challenges in Catalysis for Pharmaceuticals and Fine Chemicals V event (London, November 2nd) organized by the RSC Applied Catalysis Group.
Challenging carbon-carbon coupling achieved using visible light
Date: 27 October 2016 | Category: News
Professor Steven Ley and his team at Cambridge University have demonstrated how visible light can be used to perform complex photoredox cross-couplings in continuous flow. In an elegant paper, Professor Ley and his team have again shown how continuous flow chemistry can be a tool for new synthesis and reaction efficiency.
Spotlight on Vapourtec at IMRET
Date: 31 August 2016 | Category: News
Vapourtec will be exhibiting and demonstrating at the 2016 IMRET (International Conferences on MicroREaction Technology) conference in Beijing (Sept 11-14).
As well as Product displays (Booth 10), Vapourtec’s continuous process technology will be highlighted in two speaker presentations.
Flow chemistry chlorination
Date: 30 August 2016 | Category: News
The Vapourtec E-Series has been at the core of a recent paper describing continuous flow chlorine generation. In the exciting paper, the Kappe group of the University of Graz, Austria, has used the Vapourtec E-Series to develop in situ chlorine generation in continuous flow. The group have been able to liberate elemental chlorine in small quantities from common reagents to saturate an organic phase.
The chlorine rich organic phase was used by the Kappe group to chlorinate silanes, oxidise alcohols, and making use of the Vapourtec UV-150 continuous flow photochemical reactor, chlorinate a range of substituted toluenes.
This is a clear demonstration of how flow chemistry can be used to reduce the risks of working with such a potentially hazardous reagent as chlorine, with the easy to use Vapourtec E-Series an ideal system for flow investigations.
Continuous photochemical aryl amination
Date: 15 August 2016 | Category: News
An exciting new approach to nickel catalysed C-N coupling has been explored by Corcoran et al. of Professor MacMillan’s group, Princeton University. The new method uses nickel(II) salts that are reduced in situ to nickel(0) under mild conditions using photoredox catalysis.
The Vapourtec UV-150 continuous flow photochemical reactor has been at the heart of the group’s progress in using this new method in continuous flow, resulting in high chemical yields at a fraction of the batch reaction time.
Photochemical trifluoromethylation in continuous flow
Date: 05 August 2016 | Category: News
Vapourtec’s UV-150 continuous photochemical reactor has been used in a scale-up of an innovative approach to trifluoromethylation, with exciting results.
Professor Stephenson’s group at Michigan University have developed a photochemical trifluoromethylation method generating CF3 radicals in situ, however the batch scale-up suffered from common barriers such as poor light penetration. Using the Vapourtec UV-150 photochemical reactor a significant increase in yield was observed, demonstrating how the use of a commercial continuous flow photochemical reactor can have significant advantages when applied to novel synthesis.
Headline News
Vapourtec unveils versatile SF-10 pump
Date: 06 July 2016 | Categories: Headline News, News
Vapourtec have launched the SF-10 laboratory reagent pump offering both precision and versatility and opening up a broad range of important applications within biology and chemistry labs worldwide.
Zing conference proves a big hit
Date: 26 May 2016 | Category: News
The recently held Zing Conference in Portugal is becoming a key fixture in the continuous process chemistry calendar according to Duncan Guthrie, founder and MD of flow chemistry engineering specialists Vapourtec.
Duncan, who delivered a presentation during the event entitled ‘Photochemistry in Flow’, commented: “The 4th Zing flow chemistry conference is becoming a big event in the field of flow chemistry.
Thai distributor links up with Vapourtec
Date: 12 May 2016 | Category: News
Flow chemistry engineering specialists Vapourtec (Cambridge, UK) has extended its reach across South East Asia after signing a distribution agreement with Thailand-based ACI (Applied Chemical & Instrument Company).
The partnership with ACI is well timed given Vapourtec’s presence at the forthcoming Drug Development International Conference in Phuket where they will be exhibiting their easy-MedChem E-Series system.
Chemisky and Vapourtec deliver Korea seminars
Date: 18 April 2016 | Category: News
Vapourtec recently linked up with Korean distribution partner Chemisky to organize and deliver two engaging flow chemistry seminars in Daejeon and Seoul.
Duncan Guthrie, founder and MD of Vapourtec, commented: “The seminars proved to be very successful with over 80 taking part in total at the two venues”
New application note released: Selective oxidation using 50% hydrogen peroxide
Date: 14 April 2016 | Category: News
The key features of this flow chemistry application note include:
• Safe and controlled reaction with 50 wt.% hydrogen peroxide.
• Highly selective oxidation of sulphoxide formstion from thio ether.
• Optimal output of 225 g/h with a single reactor (37.8 kg/week).
• Demonstration of the safety features incorporated into Vapourtec systems.
Ley Group control carbon monoxide generation in flow
Date: 14 April 2016 | Category: News
A recent, published research breakthrough by the group of Steven Ley at the University of Cambridge has led to the ‘Controlled generation and use of CO in flow’.
The paper describes the use of a tube-in-tube reactor for the safe hydrolysis of Ozalyl Chloride using a NaOH solution. This produces Carbon Monoxide in the outer stream which then passes through AF-2400 semi-permeable inner tubing to enrich reaction streams. By using this approach, carbonylations can be successfully performed in flow without the use of pressurized gas cylinders.
Vapourtec shows flow chemistry potential
Date: 11 March 2016 | Category: News
Vapourtec shows flow chemistry potential with R2S and UV-150 at Continuous Flow Technology conference
Flow chemistry engineering specialists Vapourtec will be showing their modular R-Series flow chemistry system along with the UV-150 Photochemical Reactor at the Continuous Flow Technology conference (Cambridge, March 14-16).
Opening up novel, forbidden chemical space
Date: 11 February 2016 | Category: News
Vapourtec’s continuous flow technology has played a key role in a recent breakthrough announced in Chemistry World by Steven Ley’s University of Cambridge team.
Professor Ley’s team has managed to harness an explosive chemical class to create organic molecules and form novel bonds between carbon atoms.
The process involves continuously diluted, small volume flows of highly reactive diazo reagents to form up to four carbon-carbon bonds without any isolation of intermediate molecules.
R-Series
The Vapourtec R-Series is, quite simply, unrivalled for flow chemistry
- Flexible |
- Precise |
- Automatable
The R-Series is undoubtedly the most versatile, modular flow chemistry system available today.
E-Series
The Vapourtec E-Series is the perfect introductory system for flow chemistry
- Robust |
- Easy to use |
- Affordable
The E-Series is a robust and affordable, entry level flow chemistry system designed for reliability and ease of use.
Laboratory teaching manual available
Teaching the principals and benefits of continuous flow chemistry is now commonplace in University and Industrial settings alike.
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