All News

Continuous flow of breakthroughs for Vapourtec

high intensity UV light reactor

Date: 11 December 2014 | Category: News

Flow chemistry systems designed and manufactured by Suffolk (UK) based Vapourtec have recently reached the impressive milestone of having been cited in 150 peer review publications. By way of a comparison Vapourtec’s two closest competitors in flow chemistry technology have been mentioned in 51 and 40 publications respectively.

Chemical assembly systems: Layered control for divergent, continuous, multistep syntheses of active pharmaceutical ingredients

high intensity UV light reactor

Date: 03 December 2014 | Category: News

Using the Vapourtec R-Series flow chemistry system researchers from the Max-Planck Institute of Chemistry and Biology have developed an approach to deliver a range of active pharmaceutical ingredients (API’s) in a continuous process. The concept uses a non-iterative chemical assembly system that uses a range of flow chemistry modules that can be linked and interchanged to gain access to an increased chemical space.

Continuous flow magnetisation of functionalized heterocycles and acrylates with the Knochel-Hauser base (TMPMgCl·LiCl)

high intensity UV light reactor

Date: 03 December 2014 | Category: News

Using the Vapourtec E-Series flow chemistry system researchers from the Ludwig-Maximilians-Universitat Munchen have shown a procedure for functionalizing a range of heterocycles and various sensitive acrylates using the strong, non-nucleotide Knochel-Hauser base TMPMgCl.LiCl and the subsequent quenching with various electrophiles. The ability of the advanced Vapourtec V-3 pump to continuously process reagents of this type allows for the multi-gram scale-up of these reactions previously limited to small scale.

MOF research goes with the flow approach

high intensity UV light reactor

Date: 14 October 2014 | Category: News

Recently published research into the production of Metal-Organic Frameworks (MOFs) utilising Vapourtec flow chemistry technology has revealed the substantial benefits of adopting a continuous flow process over the traditional batch approach. MOFs exhibit similar structures to naturally occurring Zeolites however their properties can be synthetically tuned providing a multitude of potential industrial applications including the storage, separation and triggered release of gases, drug molecules or toxins due to the porous nature of MOF compounds.

Photochemistry potential revealed in application notes

LED Lamp

Date: 07 October 2014 | Category: News

The incredibly powerful potential of photochemistry is revealed in four application notes recently posted by Suffolk-based flow chemistry engineering firm Vapourtec. The four application notes cover ‘Synthesis of Artemisinin using E-Series and UV-150 reactor’ (Application Note 39), ‘α-Photodecarboxylation of Phthaloyl Glycine’ (38), ‘Photochemical Transformation of Methyl Coumalate’ (37) and ‘[2+2] Photocycloaddtion of Maleimide and 1-Hexyne’ (36).

Flow v batch photochemistry: A like for like comparison

vapourtec photochemical reactor

Date: 24 September 2014 | Category: News

There are a number of key advantages of a continuous flow approach to photochemistry over a traditional batch method including consistent light penetration, controlled exposure times, precise temperature control and easy scalability as well as the removal of photochemical products from the irradiated area. Comparing the two methods when it comes to the Photochemical Transformation of Methyl Coumalate reveals the substantial efficiencies and economies that can be accrued from the flow chemistry route.

Continuous synthesis of artemisinin-derived medicines

Anti-malarial-API-Prof_Seeberger

Date: 17 September 2014 | Category: News

Using the Vapourtec R-Series flow chemistry system researchers from the Max-Planck Institute of Colloids and Interfaces have developed an inexpensive, large scale synthesis of a range of anti-Malaria drugs under continuous flow conditions. The continuous, divergent synthesis system is coupled to continuous purification and is capable of producing four anti-malarial APIs.

Vapourtec sees flow chemistry growth in India

R-Series flow chemistry system

Date: 08 September 2014 | Category: News

UK chemistry engineering firm Vapourtec is establishing a burgeoning market for its flow chemistry systems across India with the continued development of a distribution partnership with Mumbai-based Pi-Process Intensification. Pi-Process Intensification have been acting as distributors for Vapourtec’s R-Series systems for the past three years and will now also be distributing their E-Series system.

New arrival at Vapourtec

E-Series-flow-photocemistry-reactor

Date: 19 August 2014 | Category: News

Suffolk (UK) flow chemistry specialists Vapourtec has welcomed a new addition to its expanding team with the appointment of Stacey Crane as Sales Specialist.

Multistep flow synthesis of 5-Amino-2-aryl-2H-[1,2,3]-triazole-4-carbonitriles

hazardous diazonium intermediates, dissolved ammonia and a novel catalytic copper oxidative cyclisation

Date: 10 August 2014 | Category: News

Using the Vapourtec R-Series flow chemistry system researchers from the UCB Biopharma have shown the development and preparation of an improved synthesis of 2-substituted 1,2,3-triazoles over conventional batch processes. Using the advantages of flow chemistry the group were able to scale up the process that involved the use of hazardous diazonium intermediates, dissolved ammonia and a novel catalytic copper oxidative cyclisation.

Continuous-flow oxidative cyanation of primary and secondary amines using singlet oxygen

high intensity UV light reactor

Date: 23 July 2014 | Category: News

Using the Vapourtec R-Series flow chemistry system researchers from the Max-Planck Institute for Colloids and Interfaces have shown a process were primary and secondary amines can be oxidised quantitatively using singlet oxygen to the corresponding imine. This chemistry developed by the group at Max-Planck again shows the innovative use of continuous photochemistry for efficient chemical transformations.

Continuous flow carbonylation reactions eliminating the use of toxic carbon monoxide gas

high intensity UV light reactor

Date: 04 June 2014 | Category: News

Using the Vapourtec R-Series flow chemistry system researchers from Janssen Research and Development (Spain), the University of Leuven and the Universidad de Castilla-La Macncha have shown a continuous flow process for carbonylation reactions without the need of toxic carbon monoxide gas and have shown new chemical reactivity under flow conditions that were not previously possible under batch conditions.

Cutting edge flow and photochemistry on show in Budapest

e-series_teach01

Date: 27 May 2014 | Category: News

Two of the world’s leading flow chemistry systems as well as the latest addition to the field of photochemistry technology will be on show at Chemspec Europe on 18-19 June and IMRET (Conference on Microreaction Technology) 23-25 June. Both events take place in Budapest, Hungary…

Headline News

Anti-malarial drug breakthrough

Artemisinin

Date: 23 May 2014 | Categories: Headline News, News

Scientists at the Max Planck institute have unveiled a breakthrough synthesis method for the drug Artimesinin that could make effective malaria treatment affordable for > 200 million worldwide sufferers.

The synthesis uses a Vapourtec flow chemistry system and a photo reactor.

Headline News

Sun shines on Vapourtec R-Series down under

barrier_reef

Date: 02 April 2014 | Categories: Headline News, News

Vapourtec’s R-Series flow chemistry system has played its part in another significant breakthrough with the development in Australia of a brand new sun cream based on mimicking the natural protection to sunlight created by coral in the Great Barrier Reef.

Vapourtec R-Series sales top 200

rseries04

Date: 17 February 2014 | Category: News

Chemistry engineering specialists Vapourtec (Suffolk, UK) has seen its flagship R-Series flow chemistry system reach a notable milestone with global sales recently reaching the 200 mark. The R-Series has a wide range of applications and is already used around the world by many major companies including BP, Pfizer, GSK, Sanofi, Novartis and Johnson & Johnson.

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