Photodecarboxylative addition of phenylacetic acid to N-methyl phthalimide

This application note illustrates the use of the Vapourtec UV-150 photochemical reactor for the photodecarboxylative benzylation of N-methyl phthalimide. The transformation has been systematically optimized in terms of reagent concentration and residence time. The optimized procedure was subsequently performed on large-scale, achieving a productivity of 1.34 g (88%) of product per hour (or 32.16 g per day). The reactor enabled continuous photochemistry in an easy-to-use, safe and efficient manner.

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