Photochemical hydration and scale-up of an anti-cancer candidate

In our application note 59 we found an unexpected photohydration taking place, instead of a cycloaddition during a photochemical library synthesis of [2+2] cycloadducts. Investigating further, we learned that it has not been reported in continuous flow in the literature before. We decided to explore this reaction further in this application note, which describes:

– Efficient and clean functionalisation of a candidate for an anti-cancer pharmaceutical

– New reaction for continuous flow

– Rapid investigation of reaction conditions, enabling double the throughput

– Optimisation of a photochemical reaction

– Throughput of 0.67 g/hr from a photochemical reaction

– Isolated yield of 80% with 99% purity

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