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In our application note 59 we found an unexpected photohydration taking place, instead of a cycloaddition during a photochemical library synthesis of [2+2] cycloadducts. Investigating further, we learned that it has not been reported in continuous flow in the literature before. We decided to explore this reaction further in this application note, which describes:
– Efficient and clean functionalisation of a candidate for an anti-cancer pharmaceutical
– New reaction for continuous flow
– Rapid investigation of reaction conditions, enabling double the throughput
– Optimisation of a photochemical reaction
– Throughput of 0.67 g/hr from a photochemical reaction
– Isolated yield of 80% with 99% purity
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