Application Note 62: Synthesis of pharmaceutical intermediate by cross-coupling with non-stabilised diazo compounds

After the Ley group, of the University of Cambridge, published a fascinating method of generating nonstabilised diazo compounds using a photochemical method,1,2 the team at New Path Molecular Research have applied the method to increase the product throughput of the synthesis of a pharmaceutical intermediate, using a newly developed high-power low-pressure mercury lamp.

This application note describes:

• The use of a 28 W low-pressure mercury
  lamp at 310 nm
• The effective, 3-fold increase in product
  throughput of a pharmaceutical
  intermediate