Application Note 62: Synthesis of pharmaceutical intermediate by cross-coupling with non-stabilised diazo compounds

    Application note 62 low pressure mercury photochemistry

    After the Ley group, of the University of Cambridge, published a fascinating method of generating nonstabilised diazo compounds using a photochemical method,1,2 the team at New Path Molecular Research have applied the method to increase the product throughput of the synthesis of a pharmaceutical intermediate, using a newly developed high-power low-pressure mercury lamp.

    This application note describes:

    • The use of a 28 W low-pressure mercury
      lamp at 310 nm
    • The effective, 3-fold increase in product
      throughput of a pharmaceutical
      intermediate
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