Application notes

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The following application notes show the range of synthesis that are possible with the Vapourtec system.

Peptide-Builder high throughput automated peptide synthesizer

High throughput synthesis of peptides with high crude purity

Application Note 80 – December 2025

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Automated Resin Cartridge Carousel on Peptide-Builder

Synthesis of N-methylated peptides in continuous flow

Application Note 81 – November 2025

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Suzuki-Miyaura coupling using CSTRs

Suzuki-Miyaura coupling using CSTRs

Application Note 79 – February 2025

  • Heterogeneous catalysis
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Cleavage of oligonucleotides in continuous flow

Cleavage of oligonucleotides in continuous flow

Application Note 78 – February 2025

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This application note illustrates the capabilities of Vapourtec’s flow chemistry systems in the field of solid-phase oligonucleotide synthesis in continuous flow.

Solid-phase oligonucleotide synthesis DNA 9-mer

Application Note 77 – July 2024

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Enzymatic synthesis of melatonin in flow

Enzymatic synthesis of melatonin in flow

Application Note 76 – July 2024

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CSTR_safety_screen_pressurised_reactions

Controlled Stevens oxidation – CSTR

Application Note 75 – January 2024

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CSTR_safety_screen_pressurised_reactions

Scale up of a SNAr reaction to >10 kg a day with CSTRs

Application Note 74 – December 2023

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Use of CSTR for biphasic reaction scale up

Application Note 73 – June 2022

  • General synthesis
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Cleaving peptides in flow

Application Note 72 – November 2021

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