Application Note 74: Scale up of a SNAr reaction to >10 kg a day with CSTRs

In this application note from Vapourtec, the first installment in a series focused on continuous stirred-tank reactors (CSTR), the application scope of CSTR for reaction scale-up is showcased. The note illustrates the challenges posed by the aromatic substitution of 3,4-difluoronitrobenzene with morpholine, resulting in a poorly soluble product accompanied by equimolar amounts of fluoride salt. This specific reaction has the potential to lead to precipitation and blockages in tubular reactors.