We have a long-standing excellent relationship with Vapourtec and use Vapourtec’s R-Series, E-Series, SF-10 pumps and Ion reactor on a daily basis. This has enabled the delivery of many advanced organic chemistry outcomes and breakthroughs, in terms of synthesis and in demonstrating the power of flow chemistry, it’s efficiency, effectiveness and high throughput/scaleup.

We carry out multiple reactions autonomously and effectively which massively improves work output. Vapourtec are a highly professional and passionate supplier of equipment of exceptional quality and engineering and technical excellence. Their drive for improvements in excellence has no bounds.

This was further demonstrated when we approached them recently for help with a challenging issue. We had a solvent/substrate system that was challenging in respect of keeping the reactants in the solvent while heating to and operating at temperature due to sublimation and precipitation. Vapourtec suggested a pressurised CSTR system which would provide the first step in our synthesis.

We could then use the CSTR to feed our Vapourtec tubular reactor for the second step of synthesis via a pair of heated SF-10+ pumps. These pumps prevent precipitation during pumping and act as a back-pressure regulator. The system proved itself immediately, as the first step of synthesis via the CSTR was reduced from 4 hours to 10 minutes with full conversion of the starting material to product. The generous support of the whole team at Vapourtec is hugely appreciated!

Dr Lee Edwards

The automation on the Vapourtec R-Series flow reactor really helps our users to get the most from their visits to the Centre for Rapid Online Analysis of Reactions (ROAR) facility. It allows us to quickly setup a medium-throughput series of flow reactions and have the reactor run through the night collecting samples in the fraction collector for analysis.

As one of the pioneers of flow chemistry, we have been using Vapourtec flow equipment for many years. The extremely high quality of the equipment is allowing our research to proceed not only using frequently modified set-ups, but also enables us to perform almost any chemistry. The automation capabilities, including especially the electrochemical equipment, has offered high productivity while the competent support from Vapourtec allows fast troubleshooting.

I really enjoy working with Vapourtec, they are an enthusiastic team who enjoy the challenge of how to build complex systems in flow. Their broad range of apparatus is easy to use and covers most of my research needs, my students particularly appreciate that each piece can be simply operated or linked for automation.

Working with actively crystallising systems is particularly challenging for flow operations and the Vapourtec team are keen to develop new technology with me to address these challenges. In terms of slurry delivery, their pumps are the best I’ve come across for combined control and low risk of pump failure.

Dr. Robertson

Vapourtec flow equipment is used routinely and for many different applications in our research group, be it for safely exploiting high-energy intermediates, performing photochemical cascades or scaling reactions. Its robustness and modularity are key in allowing postgraduate students to easily integrate different flow modules and advance their projects. The availability of newly developed flow reactor components together with the excellent support infrastructure from Vapourtec enables our team to succeed in our mission.

Marcus Baumann

The Vapourtec E-Series flow chemistry system is an incredibly versatile tool for a variety of different chemistry research fields enabled by the broad selection of reactors. We frequently use the UV150 photochemical reactor for our own research, however other reactors such as the copper coil and thermal coils have enabled fruitful collaborations with other researchers, ranging from organometallics to bioconjugation.

The simplicity and user-friendly interface of the E-Series reactor allows new students and collaborators to become competent in using the equipment rapidly. Additionally, all key components of the reactor are easily accessible which allows for easy maintenance and troubleshooting, for example, in case of a blockage within a reactor. The built-in fail safes for monitoring reactor temperature and pump pressure are great for ensuring safety and preventing damage. We cannot recommend Vapourtec highly enough to anyone interested in flow chemistry research – their products are powerful and versatile for a broad range of chemistry research, and they continue to develop new reactors and technologies to further expand this.

Their customer service and technical support is unparalleled, and they have previously loaned us equipment to allow our research to progress while repairing our own, highlighting their excellent attitude towards supporting academia.

All our communications with Vapourtec support via email, phone, online calls, or in person at conferences have always been fruitful and a pleasure, with rapid responses on technical support. The team at Vapourtec really cares about the science and will advise you on what options are best for a particular project. Its also great that Vapourtec are open to collaborating on product design, application notes and hosting research posters and presentations on their website’s resource centre.

Filipe Vilela

EMD Serono is the biopharmaceutical division of Merck KGaA, a leading science and technology company. With a focus on developing innovative therapies in the areas of neurology, oncology, fertility, and endocrinology, EMD Serono is committed to improving the lives of patients worldwide. Through their research and development efforts, EMD Serono has brought many groundbreaking treatments to market and continues to push the boundaries of what is possible in the field of biopharmaceuticals.

Since 2010 we have been working in the implementation of flow chemistry in drug discovery in order to put on the bench reactions not usually run a medicinal chemistry lab. Vapourtec instrumentation, R- and E-Series, has been very helpful to achieve this goal due to its easy open access software and the robustness of the systems that allowed us full reproducibility of results regardless the scale we use. In recent years, the implementation of Vapourtec automated flow reactors has allowed us to prepare compound libraries, either using traditional coils or photochemical reactors, and expand our capabilities to other Janssen sites.

Jesus Alcazar