Publications

Peer reviewed publications citing Vapourtec

The following (non-exhaustive) list of papers shows peer-reviewed work that has been published using the Vapourtec R-Series and E-Series flow chemistry systems.  As new work is continually published, please check here for updates.

Use the filter tools to see the chemical applications that are possible, but note that most published papers will require a journal subscription.

Download a list of all publications citing Vapourtec

Publication

Insights into Flow and Continuous Systems in Pharmaceutical Manufacturing: Challenges and Opportunities

Growth and development of the pharmaceutical sector in Ireland has been remarkable over a 50 year period starting as an API manufacturing hub with strong regulatory confidence gradually expanding to include a range of activities ranging from process R&D, formulation services,...

Insights into Flow and Continuous Systems in Pharmaceutical Manufacturing Challenges and Opportunities
  • Daly AM1
  • Hardiman S2
  • Hogan D1
  • Morris G3
  • Moylan R4
  • O'Donovan B1
  • Power E5
  • Phillips P6
  • Robinson S7
  • Roth PMC8
  • Smyth M9
  • Magner E10,11
  • Arthur A11
  • McGlacken GP11,12
  • Baumann M11,12
  • Maguire AR11,12,13
  •   1Pfizer Ringaskiddy, Co. Cork P43 X336, Ireland
  • 2Arran Chemical Company, Monksland Industrial Estate, Monksland, Athlone, Co. Roscommon N37 DN24, Ireland
  • 3APC Ltd., Building 11, Cherrywood Business Park, Loughlinstown, Co. Dublin D18 DH50, Ireland
  • 4 Eli Lilly, Dunderrow, Kinsale, Co. Cork P17 NY71, Ireland
  • 5SK Biotek, Swords Watery Lane, Swords, Co. Dublin K67 AY91, Ireland
  • 6MSD Ballydine, Ballydine, Kilsheelan Clonmel, Co. Tipperary, E91 V091, Ireland
  • 7J&J Innovative Medicines Little Island Industrial Estate, Little Island, Co. Cork T45 P663, Ireland
  • 8Willy A. Bachofen AG Switzerland, Junkermattstrasse 11, Postfach 944, Muttenz 1 CH-4132, Switzerland
  • 9Almac Sciences, Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD, Northern Ireland
  • 10Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland
  • 11SSPC, The Research Ireland Centre for Pharmaceuticals Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland
  • 12School of Chemistry, University College Cork, College Road, Cork T12 YN60, Ireland
  • 13School of Pharmacy, University College Cork, College Road, Cork T12 YN60, Ireland
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Publication

Ruppert–Prakash Reagent as a Source of Difluorocarbene: Mechanistic, Synthetic, and Practical Perspectives for Small-Ring Synthesis

The Ruppert–Prakash reagent (TMSCF3) has become one of the most practical and widely used sources of difluorocarbene, enabling the efficient construction of gem-difluorocyclopropane and gem-difluorocyclopropene frameworks. Over the past decade, significant progress has been mad...

Ruppert–Prakash Reagent as a Source of Difluorocarbene: Mechanistic, Synthetic, and Practical Perspectives for Small-Ring Synthesis
  • General synthesis
  • Scale-up
  • Ryabukhin S1,2,3,4
  • Nosik P1,2,3
  • Leha D2,3
  • Volochnyuk D1,2,3,4
  •   1Enamine Ltd. 78 Winston Churchill str. Kyiv 02094 Ukraine
  • 2Taras Shevchenko National University of Kyiv, 60 Volodymyrska str., Kyiv, 01033 Ukraine
  • 3Enamine Scientific Research Institute, 78 Winston Churchill str., Kyiv, 02094 Ukraine
  • 4Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, 5 Akademik Kukhar str., Kyiv, 02094 Ukraine
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Publication

Flow-Enabled Deuteration of Saturated Fatty Acids over Platinum Group Metals: Mechanistic and Process Insights

Metal-catalyzed hydrothermal deuteration is a versatile approach for hydrogen–deuterium exchange (HDE) reactions, offering precise isotopic labeling of organic molecules. Here, we report the development of a scalable flow deuteration method that permits the tunable isotopic sel...

Flow-Enabled Deuteration of Saturated Fatty Acids over Platinum Group Metals Mechanistic and Process Insights
  • Heterogeneous catalysis
  • Mensah J1
  • Jampaiah D2
  • Kokate R3
  • Kumar P3
  • Karatchevtseva I1
  • Zhang Y1
  • Moir M1
  • Darwish T1
  •   1Australian Nuclear Science and Technology Organisation, National Deuteration Facility, New Illawarra Road, Lucas Heights, New South Wales 2234, Australia
  • 2Centre for Advanced Materials and Industrial Chemistry (CAMIC), RMIT University, Melbourne, Victoria 3000, Australia
  • 3School of Chemical Engineering, UNSW, Sydney, New South Wales 4072, Australia
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Publication

Chemical recycling of hydrofluorocarbons by transfer fluorination

Fluorochemicals improve our quality of life; however, there is increasing concern over how they are produced and their negative effects on health and the environment. Here we report an approach to the recycling of fluorochemicals. Treatment of hydrofluorocarbons with a potassium ...

Chemical recycling of hydrofluorocarbons by transfer fluorination
  • Jenek NA1
  • Brock SL1
  • Mao J1
  • Fogh AA1
  • Phanopoulos A1,2
  • Crimmin MR1
  •   1Department of Chemistry, Imperial College London, London, UK
  • 2Department of Chemistry, University of Bath, Bath, UK
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Publication

Photocatalytic Amino and Alkoxy Carbonylation Reactions in Flow Using [Co2(CO)8]

A cobalt mediated photocarbonylation reaction, whereby [Co2(CO)8] acts as a catalyst and carbon monoxide surrogate, has been developed and translated to flow for the preparation of amides and esters. The flow process is technically straightforward, does not require CO gas handlin...

  • Photocatalysis
  • Martínez-Aguirre M1
  • Bailey R1
  • Schaefer B2
  • Crimmin M1
  • Miller P1
  •   1Molecular Sciences Research Hub, Imperial College London, Wood Lane, White City Campus, London, UK, W12 0BZ
  • 2BASF, Ludwigshafen am Rhein, Rhineland-Palatinate, Germany
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