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Gold nanoparticles enable heterogeneous tandem cyclisation / hydroalkoxylation process

Authors: Kristína Plevová, Véronique Michelet and Sylvain Antoniotti Sylvain Antoniotti, Kristína Plevová and Véronique Michelet, from the Université Côte d’Azur, have successfully used the Vapourtec R-Series system to achieve scale-up of a tandem cyclisation/hydroalkoxylation process using heterogeneous gold nanoparticles supported on TiO2. In particular, the use of flow allowed scale-up by a factor of 10 […]

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Enhancing the cleavage of Oligonucleotides

We are excited to be able to share the work of Scientists at Novo Nordisk who have applied flow chemistry to enhance the cleavage of oligonucleotides. The improvements reported are: Reducing the time for cleavage and complete deprotection to less than 3 minutes. Eliminating the risks associated with batch reactors having pressurised headspace. Producing repeatable […]

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Immobilised biocatalyst facilitates flow route to Danshensu

Authors: Valentina Marchini, Francesca Paradisi Valentina Marchini and Francesca Paradisi from The University of Bern have used a packed-bed reactor mounted within the Vapourtec R-Series modular flow chemistry system to synthesise danshensu [1], a pharmacological agent with significant use in traditional Chinese medicine. Starting from L-dopa, preparation of danshensu was achieved with a co-immobilised bioenzymatic system […]

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