World-class peptide synthesizers from Vapourtec
Vapourtec offers a range of best-in-class peptide synthesizers designed for fast-flow solid phase peptide synthesis (SPPS), supporting scales from 0.05 mmol up to 30 mmol. Ideal for short and long, linear and branched peptides, including sequences of 70-mers and beyond.
At the heart of the system is Vapourtec’s patented Variable Bed Flow Reactor (VBFR) technology. This core feature with single pass flow significantly improves cycle efficiency while reducing solvent and reagent consumption, delivering high-purity, high-yield peptides with lower running costs and minimal waste over traditional methods.
With exceptional technical and after-sales support, we take pride in supporting our customers throughout the entire lifecycle of the system.
- Higher quality crude peptides
- Ideal for short and long peptides, including sequences of 70-mers and beyond
- Fast cycle times, even at large synthesis scales
- Continuous in-line analytics, including resin solvation monitoring and UV absorption data
- Includes an industry-leading sequence generator with automated side-chain modifications
- Lower reagent and solvent consumption than conventional systems
- Seamless scale-up from lab to 30 mmol without the need for process redevelopment
- Outstanding reproducibility across batches
- Uniform heating via conduction eliminates hot spots and ensures consistent results
- Reduced running costs through improved reagent efficiency
- Supports greener chemistry practices with minimized waste and optimized workflows
Trusted by leading institutions
Vapourtec’s products are trusted by all major pharmaceutical companies and have been referenced in over 1,250 peer-reviewed publications.
Peptide-Builder
The Peptide-Builder is designed for peptide chemists who want to make high quality peptides quickly and easily at laboratory scale. Peptides are synthesized sequentially fully automated either one at a time or queued up to 16, for example overnight.
- Synthesis scale 0.05 mmol to 1.0 mmol
- Sequential synthesis up to 16 peptides at any time
- Patented VBFR™ technology for high-purity, high-yield peptides
- Short cycle time ~6 minutes per residue, total coupling, deprotection and washing
- Fmoc solid phase peptide chemistry with DIC and oxyma activation
- In-line data, including UV/vis, resin volume, Fmoc AUC and more
- Industry leading software with sequence generator and automated side chain modifications
- Compact space-saving design
- Minimises solvent and reagent usage compared with competing products
- Green solvent compatible
Peptide-ExplorerLT
The Peptide-ExplorerLT is a fast-flow peptide synthesiser designed for peptide chemists who want a flexible yet compact synthesiser for making and optimising linear peptides at scale between 0.05 mmol and 1 mmol.
- Compact footprint
- Low price point
- Synthesis scale 0.05 – 1.00 mmol
- Ideal for research
- State of the art peptide synthesis software including sequence generator and real-time presentation of in-line analytic data
- Uses Vapourtec’s patented reactor technology for continuous flow single pass SPPS
- Fmoc solid phase peptide chemistry with DIC and oxyma activation
- Minimises solvent and reagent use compared with competing products
- Continuous in-line analytics including resin solvation data and UV absorption data
- Fast cycle times even at larger scale
Peptide-Explorer
The Peptide-Explorer is designed for scientists who need to explore and optimise peptide chemistry and ultimately scale-up. The product is a high spec flow chemistry system adapted for continuous flow peptide synthesis and has comprehensive flexibility and analytical capability with proven reliability over 15 years of operation.
- Synthesis scale 0.05 – 1.00 mmol
- Ideal for research
- State of the art peptide synthesis software including sequence generator with automated addition of side chain(s)
- Uses Vapourtec’s patented reactor technology for continuous flow single pass SPPS
- Fmoc solid phase peptide chemistry with DIC and oxyma activation
- Minimises solvent and reagent use compared with competing products
- Continuous in-line analytics including resin solvation data and UV absorption data
- Fast cycle times even at larger scale
- This is a highly flexible product capable of peptide synthesis and continuous flow organic small molecule synthesis including photochemistry and electrochemistry
Peptide-Scaleup
The Peptide-Scaleup is designed for the peptide chemist aiming to scaleup their peptides where synthesis time is critical. The Peptide-Scaleup is an advanced alternative to traditional room temperature batch scaleup peptide synthesizers. Typically a 30-mer peptide can be synthesized at 4 mmol scale in just 16 hours.
- Synthesis scale 0.5 mmol to 5.0 mmol
- Highest quality crude peptides at large scale, minimises demands on purification
- Heated reactors (VBFR) ensures fast cycle times even at largest scale
- State of the art peptide synthesis software including sequence generator with automated addition of side chain(s)
- Uses Vapourtec’s patented reactor technology (VBFR) for continuous flow single pass SPPS
- Fmoc solid phase peptide chemistry with DIC and oxyma activation
- Minimises solvent and reagent usage compared with competing products
- Continuous in-line analytics including resin solvation data and UV absorption data
- A synthesis optimised on the Peptide-Explorer can be transferred to the PS-30 pilot scale peptide synthesizer without further development
PS-30 pilot scale peptides
The PS-30 pilot scale peptide synthesizer is a unique peptide synthesizer designed to reduce the drug development cycle time by reducing the time required to produce significant quantities of a target peptide. Synthesis times are reduced from weeks to less than a day when compared with the normal room temperature batch methods. Crude purity is excellent even when non-natural amino acids are required.
- Product available to order now
- Synthesis scale 2.0 mmol to 30.0 mmol
- Highest quality crude peptides at large scale
- Heated reactors (VBFR) ensures fast cycle times even at largest scale
- Typical reaction time for a 30-mer peptide at 30 mmol scale is 15 hours
- Uses Vapourtec’s patented reactor technology (VBFR) for continuous flow single pass SPPS
- State of the art peptide synthesis software including sequence generator with automated addition of side chain(s) and real time analysis of synthesis quality
- Fmoc solid phase peptide chemistry with DIC and oxyma activation
- Minimises solvent and reagent usage. Solvent usage typically less than 140 ml per mmol / cycle even when using PEG resins
- Continuous in-line analytics including resin solvation data and UV absorption data
- A synthesis optimised on the Peptide-Explorer can be transferred to the PS-30 pilot scale peptide synthesizer without further development
