Unlocking BODIPY dye synthetic methodologies with 1H NMR monitoring and continuous flow techniques

An optimized synthesis of BODIPY dyes is reported, combining batch and continuous flow techniques for enhanced efficiency. 1H NMR monitoring indicated rapid dipyrromethane formation, completing within 2 min compared to traditional multi-hour reaction times. The condensation/oxidation steps were integrated into a continuous flow process followed by batch borylation, yielding BODIPY derivatives with yields up to 84 %. This approach minimizes side-products, simplifies purification, and enables gram-scale production (to 26 g/day), broadening the applicability of these versatile dyes.

• Felgueiras, A
• Arnaut, Z
• Cebola, J
• Martins, G
• Rodrigues, F
• Bagnato, V
• de Oliveira, K
• Calvete, M
• Pereira, M

• CQC-IMS, Department of Chemistry, University of Coimbra, Rua Larga, Coimbra, Portugal

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