Two-step continuous flow-driven synthesis of 1,1-cyclopropane aminoketones

The continuous flow telescoped synthesis of 1,1-cyclopropane aminoketones was achieved through the optimization of the photocyclization of 1,2-diketones to 2-hydroxycyclobutanones (HCBs), followed by their reaction with aryl- and alkylamines via a tandem condensation C4–C3 ring contraction reaction. Under the optimized operational conditions, a library of cyclopropylamines was obtained with good chemical yields, high productivity, and short residence times.

• Velichko, V
• Moi, D
• Soddu, F
• Scipione, R
• Podda, E
• Luridiana, A
• Cambie, D
• Secci, F
• Cabua, MC

• Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, Complesso Universitario di Monserrato, 09042, Monserrato (Cagliari), Italy

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