The Transformation of Alkyl- and Aryl-Sodium Reagents with Simple Amides for the Direct Synthesis of Ketones

The transformation of alkyl and aryl sodium reagents with N-alkyl amides is described. The reaction sequence is initiated by an alkyl sodium reagent, which is generated in a flow reactor. The alkyl sodium reagent is either directly reacted with N-alkyl amides or used for the reaction with alkyl-substituted or alkoxy-substituted arenes to generate secondary sodium reagents which were then reacted with the amides to afford the desired ketones in moderate to good yields.

• Knupe‐Wolfgang, P
• Hilt, G

• Institut für Chemie, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany

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