Ruthenium‐Zeolite Catalyzed Dehydrative N‐Benzylation of Amides for the Construction of Macrolactams Under Continuous Flow

The continuous-flow synthesis of acyclic amides and macrolactams has been successfully demonstrated via N-benzylation of amides using a highly reusable heterogeneous Ru–Zeolite catalyst, with water generated as the sole by-product. A total of 30 N-benzylated acyclic amides were furnished, while intramolecular N-benzylation using alcohols was well tolerated, yielding 15 examples of macrolactams bearing 11- to 15-membered rings. Notably, the scalability of the flow process was demonstrated from milligram to gram scale using the Ru–Zeolite heterogeneous catalyst. Furthermore, the reusability of the catalyst was exemplified by 16 reaction cycles carried out using a single, pre-packed catalyst bed within the reactor.

• Bandu Jamdade, A
• Bamayya Swami, G
• Vishambar Sutar, D
• Nair, P
• Gnanaprakasam, B

• Indian Institute of Science Education and Research Pune 411008 India

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