The following (non-exhaustive) list of papers shows peer-reviewed work that has been published using the Vapourtec R-Series and E-Series flow chemistry systems. As new work is continually published, please check here for updates.
Use the filter tools to see the chemical applications that are possible, but note that most published papers will require a journal subscription.
Download a list of all publications citing Vapourtec
Screening identified 2-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylic acid (1) as a 55 µM dynamin GTPase inhibitor. Synthesis of three 1-based libraries shows no potency enhancement. However, S-isostere-based 3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxy...
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Andrew J. S. Lin1
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Nicholas S. O’Brien1
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Abigail Florence1
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Matthew Killen1
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Shelby L. Frailey1
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Jayne Gilbert2
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Jennette A. Sakoff2
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Mohammed K. Amin1
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Emily E. Castelloe1
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Ngoc Chau3
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Jing Xue3
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Phillip J. Robinson3
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Adam McCluskey1
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1Chemistry, School of Environmental & Life Sciences, The University of Newcastle, University Drive, Callaghan, New South Wales, 2308 Australia
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2Experimental Therapeutics Group, Department of Medical Oncology, Calvary Mater Hospital, Edith Street, Waratah, New South Wales, 2298 Australia
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3Children's Medical Research Institute, Cell Signalling Unit, The University of Sydney, Hawkesbury Road, Westmead, Sydney, New South Wales, 2145 Australia
Antimicrobial resistance is a growing threat to human health and agriculture. Sulfur-containing compounds and elemental sulfur have a long history of use as antimicrobials, but challenges related to solubility and formulation have limited their broad application. Recent advances ...
Relevant Applications
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Jasmine Pople1
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Ocean Clarke2
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Romy Dop2
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Thomas Nicholls1
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Harshal Patel1
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Witold Bloch1
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Zhongfan Jia1
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Sara Fraser-Miller1
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Evangeline Cowell1
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Jillian Carr1
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Bart Eijkelkamp1
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Daniel Neill3
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Joanne Fothergill2
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Tom Hasell2
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Justin Chalker1
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1Flinders University, Australia
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2University of Liverpool, United Kingdom
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3 University of Dundee, United Kingdom
Flow reactors for Solid phase synthesis (SPS) have gained attention, as they appear to be more efficient than the widely used stirred tanks. In either Packed Bed (PBR) or Loose Bed Reactors (LBR) configurations, the theoretical description of such platforms is limited. This study...
Relevant Applications
Authors
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Sebastián Pinzón-López1,2
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Wei-Hsin Hsu1,3
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Dominik Ebert1,3
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Mei-Huei Lin1,3
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Matthias Kraume2
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Peter H. Seeberger1,3
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José Danglad-Flores1
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1Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany
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2Chair of Chemical and Process Engineering, Technische Universität Berlin, Ackerstraße 76, 13355, Berlin, Germany
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3Institute of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195, Berlin, Germany
This work presents a significantly improved and scaled continuous flow process for the synthesis of Propofol (2,6-diisopropylphenol), a WHO-essential anaesthetic agent. Building upon previous research, the two-step synthesis featuring a Friedel-Crafts bisalkylation of 4-hydroxybe...
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Dr. Antoine Coeuillas1
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Dr. Aurore Ceuninck1
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Dr. Laetitia Chausset-Boissarie2
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Dr. Julien Legros2
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Prof. Philippe Jubault1
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Prof. Thomas Poisson1
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1INSA Rouen Normandie
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2Université Rouen Normandie CNRS
Chroman-2-one derivatives are biologically relevant structures that present interesting pharmacological and biological properties, being the C-4 alkylated derivatives of particular interest. The methods described in the literature allow the C-4 functionalization of coumarins with...
Relevant Applications
Authors
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Ewelina Kowalska1
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Benedetta Carli2
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José Alemán2,3
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Leyre Marzo2,3
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Anna Albrecht4
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1Institute of Organic Chemistry Lodz University of Technology Żeromskiego 116 Łódź 90‐924 Poland
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2Organic Chemistry Department. Modulo 1, Universidad Autonoma de Madrid, Madrid, 28049 Spain
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3Institute for Advanced Research in Chemical Sciences (IAdChem0, Universidad Autonoma de Madrid, Madrid, 28049 Spain
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4Institute of general and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Poland
