Photocatalytic Addition of N-Oxazolidinone Radicals to Arenes and Heteroarenes in Batch and in Flow Mode

Recent progress in N-centered radical chemistry has paved the way for unprecedented transformations in organic synthesis, particularly through photocatalytic C–N bond formation reactions. Here, unexplored N-oxazolidinone radicals are generated through visible light irradiation, enabling a novel, efficient, sustainable, and scalable C–H functionalization process of arenes and heteroarenes. Crucially, the use of continuous flow processing was found to provide further advantages over standard batch conditions, which will enable further applications of this important transformation.

• Sara Ferrario¹
• Sergio Rossi¹
• Niccolò Intini¹
• Julia Bruno-Colmenarez²
• Marcus Baumann²
• Maurizio Benaglia¹

•   ¹Dipartimento di Chimica, Università degli Studi di Milano, Via Camillo Golgi 19, 20133 Milano, Italy
• ²School of Chemistry, University College Dublin, Science Centre South, D04N2E5 Dublin, Ireland

• Request a Brochure
• Request more Info
• Request a Quote