Vapourtec Ltd
Telephone +44(0)1284 728659
Email [email protected]
A robust and efficient continuous flow setup is presented for the orchestrated use of CO₂ gas and photochemistry under flow conditions. In this study, the catalyst-free cycloaddition between azomethine ylides—generated in situ from simple 2H-azirines—and CO₂ was explored. UV-A light (365 nm) was used as the energy source, and CO₂ was employed as an inexpensive and abundant building block, providing an attractive strategy through which isomeric oxazolones were afforded. These were subsequently aromatised to yield novel oxazole products in a convergent manner. Substantial improvements in reaction performance were achieved through continuous flow processing, allowing for the safe exploitation of this transformation. In this way, effective fixation of CO₂ was enabled to generate valuable building blocks, and the process was demonstrated to be readily scalable to gram quantities.
- Bonner, A
- García‐Lacuna, J
- Baumann, M
- University College Dublin, Chemistry, Science Centre South Belfield, Dublin 4, Ireland, IRELAND
