Nonclogging Liquid-Walled Continuous Flow Reactors

Flow chemistry is rapidly growing due to its ability to outperform batch processes in terms of production costs, product quality, and overall environmental footprint. However, the reaction scope in flow is currently limited by solid handling challenges. Solids such as heterogeneous catalysts (powders) or precipitates are known to cause clogging in flow reactors, resulting in downtime for cleaning or sometimes even replacement of the reactor. Here, liquid-walled continuous flow reactors are reported, which are virtually insensitive to clogging or abrasion and provide mixing rates an order of magnitude faster than those of solid-wall analogs. Chemically inert ferrofluids are used to form the walls and are held in place with permanent magnets, resulting in a stable liquid–liquid interface. Efficient formylation of aryl bromides, typically hindered by in-line precipitation, is demonstrated using this system.

• Mata, A
• Fraipont, C
• Hervieux, C
• Giacchetti, L
• Hadj-Sassi, O
• Bogicevic, A
• Marichez, V
• Hermans, T

• Qfluidics, 850 Bd Sébastien Brant, Illkirch-Graffenstaden 67400, Cedex, France

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