NATURE-INSPIRED COMPOUNDS AS MULTI-TARGET DIRECTED LIGANDS

Microbial pathogens threaten both public health and agriculture, causing millions of deaths and major crop losses. The rise of antimicrobial resistance underscores the need for new, multi-target treatments.

This Ph.D. project focused on phytoalexins—natural defense compounds with antibacterial, antifungal, and antioxidant activity—as starting points for novel antimicrobials. Four classes were studied: myxochelins, phenolamides, stilbenoids, and strobilurins. Key compounds were synthesized via chemo-enzymatic methods and tested against plant and human pathogens.

Stilbenoids were further explored for their protective effects and molecular targets using affinity-based protein profiling. The project also designed hybrid compounds, combining natural and synthetic scaffolds to enhance potency and fight resistance, supported by virtual screening for new bioactive leads.

• Pinna, C

• UNIVERSITA DEGLI STUDI DI MILANO

• Request a Brochure
• Request more Info
• Request a Quote