Investigation into a high-p,T,c continuous flow synthesis of myristyl-γ-picolinium chloride (MGPC) – a preservative in pharmaceutical formulations

Myristyl-γ-picolinium chloride (MGPC) is an alkyl pyridine quaternary ammonium salt and a popular preservative in injectables such as Depo-Medrol (Methylprednisolone acetate). Herein we describe a successful high-p,T,c chemical intensification of MGPC synthesis from neat myristyl chloride and γ-picoline in continuous flow. The process is atom economical, scalable with low reactor footprint and under optimized conditions, consistently affords MGPC in 45 min (instead of 8-12 h reported in literature for a conventional batch process) with excellent yield (> 90%) and purity (> 99%).

• Veeramani, K
• Shinde, M
• Eda, V
• Peraka, S
• Mohan, S
• Bandichhor, R
• Oruganti, S

• 10X Chemical Process Automation Laboratory, Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad, 500 046, India

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