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In this personal perspective, hybrid-enabling technologies refer to the integration of multiple methodologies, platforms, and technologies in organic synthesis to achieve more efficient, selective and sustainable chemical reactions. These technologies often combine with traditional or classical synthetic methods towards innovative synthetic approaches to address the challenges of conventional organic synthesis. This perspective emphasizes the utilization of enabling methods, with flow chemistry at the forefront, to achieve more sustainable production of biomolecules, agrochemicals as well as pharmaceuticals.