High-Throughput Electrochemistry: State of the Art, Challenges, and Perspective

Electrochemical transformations involve complex parameter interactions, ranging from universal chemistry variables such as solvent and reagents to specialist factors including electrode material and current density. Hence, the development of a robust and scale-independent electrochemical reaction can currently be a challenge. High-throughput experimentation (HTE) is an enabling method for reaction optimization and robustness testing. Here we provide an industrial and academic perspective on the state of the art of the combination of HTE with electrochemical reaction optimization for applications, including scale-up. We then present our vision for a future in which HTE reduces barriers to wide adoption of electrochemistry across the field of chemical synthesis.

• Wills A^1,2
• Charvet S³
• Battilocchio C⁴
• Scarborough C⁴
• Wheelhouse K⁵
• Poole D¹
• Carson N⁶
• Vantourout J³

•   ¹Medicinal Chemistry, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom
• ²Department of Pure & Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom
• ³Univ Lyon, Université Lyon 1, CNRS, INSA, CPE-Lyon, ICBMS, UMR 5246, Bâtiment LEDERER, 1 rue Victor Grignard, 69622 Villeurbanne Cedex, France
• ⁴Research Chemistry, Syngenta Crop Protection, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland
• ⁵Chemical Development, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom
• ⁶Syngenta Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom

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