Enabling Technologies in High Throughput Chemistry

The historical background, strategies, and methods that comprise the field of high throughput organic synthesis are described herein. The two primary synthesis methods, combinatorial and parallel, are compared and discussed along with their enabling technologies. Synthesis using substrates on solid support, on soluble support, and in solution are examined as well as the employment of solid-supported reagents, scavengers, and catalysts. Examples of compound libraries and synthetic methods derived from both techniques are presented to illustrate their applications, advantages, and challenges. Several enabling technologies (automation and other specialized laboratory equipment) are presented in the context of their relevance to this field.

• Allen, C
• Dissanayake, G
• Lee, C
• Zhen, J

• Vertex Pharmaceuticals, Inc, Boston, MA, United States

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